کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4324905 1613946 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impairment of fear memory consolidation and expression by antihistamines
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Impairment of fear memory consolidation and expression by antihistamines
چکیده انگلیسی

Antihistamines are widely used to treat allergy symptoms. First-generation antihistamines have adverse effects on the central nervous system (CNS), such as hypnotic and amnesic effects, whereas second-generation antihistamines have poor brain penetration, and therefore, have fewer CNS-related adverse effects. Memory consists of several phases, including acquisition, consolidation, expression, and extinction. It remains unclear whether these phases are affected by antihistamines. We investigated the effects of diphenhydramine, a first-generation antihistamine, and levocetirizine and olopatadine, second-generation antihistamines, on memory phases. Mice were subjected to fear conditioning on day 1 and tested on day 2. Antihistamines were administered before conditioning, immediately after conditioning, or before the test session. Diphenhydramine (30 mg/kg) decreased freezing time when administered immediately after conditioning or before the test session. These effects were not attributable to a change in locomotor activity. Levocetirizine (0.1, 1, 10 mg/kg) and olopatadine (1, 10, 20 mg/kg) had no effects on conditioned fear. We also examined the effect of diphenhydramine and levocetirizine on the expression of an activity-dependent gene associated with the test session. Diphenhydramine, but not levocetirizine, increased Arc transcription in the central nucleus of the amygdala. These data indicate that diphenhydramine, but not levocetirizine or olopatadine, impairs the consolidation and expression of conditioned fear.


► We examined the effect of first- and second-generation antihistamines on the memory.
► Diphenhydramine impaired memory consolidation and expression.
► Diphenhydramine increased Arc expression in the CeA during memory expression.
► Levocetirizine and olopatadine did not affect memory phases and Arc expression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1493, 1 February 2013, Pages 19–26
نویسندگان
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