Beneficial effects of sulindac in focal cerebral ischemia: A positive role in Wnt/β-catenin pathway

► pMCAO model is used to analyze sulindac's neuroprotective effect. ► Sulindac reduces the neurological deficits, infarct volumes and brain edema. ► Sulindac activates the impaired Wnt/β-catenin pathway in cerebral ischemia. ► Sulindac inhibits neuronal apoptosis in cerebral ischemia. ► Sulindac ameliorates the permeability of blood brain barrier in cerebral ischemia.