CSC counteracts l-DOPA-induced overactivity of the corticostriatal synaptic ultrastructure and function in 6-OHDA-lesioned rats

►Coadministration of l-DOPA with CSC ameliorated the rotational response duration. ►Coadministration of l-DOPA with CSC partly attenuated dyskinesia. ►CSC attenuated the upregulation of striatal adenosine A2A receptor expression. ►Coadministration of l-DOPA with CSC ameliorated the postsynaptic effects. ►Abnormal synaptic plasticity is closely associated with the development of LID.