کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4326335 1614076 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of stress on stroke recovery in a photothrombotic stroke animal model
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
The effect of stress on stroke recovery in a photothrombotic stroke animal model
چکیده انگلیسی

Background and aims: Several studies have provided convincing evidence that psychosocial factors, chronic stress and emotional factors are all independent predictors of atherosclerosis and cardiovascular events as well. However, psychosocial factors have received little attention in the medical setting. The purpose of this study is to evaluate the influence of stress on photothrombotic ischemic cortical injury in an animal model. Methods: Sprague-Dawley rats were assigned to the four groups and cortical photothrombosis was induced in the sensorimotor cortex. The stress groups were subjected to restraint stress for five days. We evaluate the behavioral function, infarct volume, apoptotic cell death and the activations of mitogen-activated protein kinases (MAPK: Erk1/Erk2, and p38MAPK) for the evaluation of stress effects on stroke. Results: There was a significant increase in cortical infarct volume and apoptotic cell death at the stroke group subjected to restraint stress (p < 0.05, and p < 0.01, respectively). The functional recovery was worst in restraint stress group during five days (p < 0.05). The activation of Erk1 and Erk2 were increased by restraint stress in sham operation group but decreased in stroke-stress group than stroke control group (p < 0.01). The activation of p38MAPK was increased by stroke but this effect was decreased by restraint stress (p < 0.05, and p < 0.01, respectively). Our data demonstrates that restraint stress increases infarction volume and decreases functional recovery in rat stroke models by modulation of the MAPK pathway.

Research Highlights
► We evaluate the effect of restraint stress on stroke recovery.
► Restraint stress increased the infarct volume and apoptotic cell death.
► Stressed-rat showed unfavorable outcome in beam-walking, beam-balance, and corner test.
► Spontaneous recovery of gross motor function was faster than that of coordination.
► Restraint stress decreased the activation of Erk1/Erk2 and p38MAPK in infarct core.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1363, 6 December 2010, Pages 191–197
نویسندگان
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