کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4326384 1614075 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Recent studies of gonadotropin-inhibitory hormone (GnIH) in the mammalian hypothalamus, pituitary and gonads
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Recent studies of gonadotropin-inhibitory hormone (GnIH) in the mammalian hypothalamus, pituitary and gonads
چکیده انگلیسی

The hypothalamo-pituitary-gonadal (HPG) axis integrates internal and external cues via a balance of stimulatory and inhibitory neurochemical systems to time reproductive activity. The cumulative output of these positive and negative modulators drives secretion of gonadotropin-releasing hormone (GnRH), a neuropeptide that causes pituitary gonadotropin synthesis and secretion. Ten years ago, Tsutsui and colleagues discovered a peptide in quail hypothalamus that is capable of inhibiting gonadotropin secretion in cultured quail pituitary cells. Later studies by a variety of researchers examined the presence and functional role for the mammalian ortholog of GnIH. To date, GnIH exhibits a similar distribution and functional role in all mammals investigated, including humans. This overview summarizes the role of GnIH in modulation of mammalian reproductive physiology and suggests avenues for further study by those interested in the neuroendocrine control of reproductive physiology and sexual behavior.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1364, 10 December 2010, Pages 62–71
نویسندگان
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