The c-Jun N-terminal kinase inhibitor SP600125 is neuroprotective in amygdala kindled rats

► SP600125 has a protective effect on hippocampal neurons in amygdala kindled rats by inhibiting JNK activation. ► JNK phosphorylation is involved in the process of hippocampal sclerosis in amygdala kindled rats. ► The amygdala kindling epilepsy model resembles the human temporal lobe epilepsy. ► JNK pathway may be a new target to interfere with the development of hippocampal sclerosis in the temporal lobe epilepsy.