کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4326591 1614085 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress
چکیده انگلیسی

Traumatic brain injury (TBI) is a leading cause of mortality and disability among the young population. It has been shown that hydrogen gas (H2) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radical (OH, the most cytotoxic ROS). Recently, we have found that H2 inhalation significantly improved the survival rate and organ damage of septic mice. In the present study, we investigated the effectiveness of H2 therapy on brain edema, blood–brain barrier (BBB) breakdown, neurological dysfunction and injury volume in TBI-challenged rats. In addition, we investigated the effects of H2 treatment on the changes of oxidative products and antioxidant enzymes in brain tissue of TBI-challenged rats. Hydrogen treatment was given by exposure to 2% H2 from 5 min to 5 h after sham or TBI operation, respectively. Here, we found that TBI-challenged rats showed significant brain injuries characterized by the increase of BBB permeability, brain edema and lesion volume as well as neurological dysfunction, which was significantly attenuated by 2% H2 treatment. In addition, we found that the decrease of oxidative products and the increase of endogenous antioxidant enzymatic activities in the brain tissue may be associated with the protective effects of H2 treatment in TBI-challenged rats. The present study supports that H2 inhalation may be a more effective therapeutic strategy for patients with TBI.

Research Highlights
► H2 inhalation has a beneficial effect on TBI in a concentration-dependent manner.
► H2 inhalation attenuates brain edema, BBB breakdown and injury volume of TBI rats.
► 2% H2 inhalation improves neurological dysfunction of TBI rats.
► The protective effects are associated with the decrease of oxidative products.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1354, 1 October 2010, Pages 196–205
نویسندگان
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