کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4326947 1614101 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MicroRNA dysregulation in psychiatric disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
MicroRNA dysregulation in psychiatric disease
چکیده انگلیسی

MicroRNAs (miRNAs) are small regulatory RNAs that individually regulate up to several hundred genes, and collectively may regulate as much as two-thirds of the transcriptome. Recent evidence supports a role for miRNA dysregulation in psychiatric and neurological disorders, including schizophrenia, bipolar disorder, and autism. Small changes in miRNA expression can fine-tune the expression of multiple genes within a biological network, suggesting that miRNA dysregulation may underlie many of the molecular changes observed in psychiatric disease, and that therapeutic regulation of miRNA levels may represent a novel treatment option.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1338, 18 June 2010, Pages 89–99
نویسندگان
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