کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4326974 | 1614106 | 2010 | 9 صفحه PDF | دانلود رایگان |
Activity-dependent changes in cortical protein expression may mediate long-term physiological processes such as sleep and neural connectivity. In this study we determined the number of nerve growth factor (NGF)- and interleukin-1β (IL1β)-immunoreactive (IR) cells in the somatosensory cortex (Sctx) in response to 2 h of mystacial whisker stimulation. Manual whisker stimulation for 2 h increased the number of NGF-IR cells within layers II-V in activated Sctx columns, identified by enhanced Fos-IR. IL1β-IR neurons increased within layers II-III and V-VI in these activated columns and IL1β-IR astrocytes increased in layers I, II-III and V as well as the external capsule beneath the activated columns. These whisker-stimulated increases in the Sctx did not occur in the auditory cortex. These data demonstrate that expression of NGF or IL1β in Sctx neurons and IL1β in Sctx astrocytes is, in part, afferent input-dependent.
Journal: Brain Research - Volume 1333, 28 May 2010, Pages 48–56