کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4328891 | 1614199 | 2008 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Excitatory pathways from the vestibular nuclei to the NTS and the PBN and indirect vestibulo-cardiovascular pathway from the vestibular nuclei to the RVLM relayed by the NTS
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کلمات کلیدی
ventral subnucleusIRTVGLUTintermediate reticular nucleusaCSFSpVeNMDAN-methyl-d-aspartateBDAfluoro-goldMVENTSPBNRVLMSp5 - sp5Immunoreactivity - ایمنی فعالImmunohistochemistry - ایمونوهیستوشیمیfourth ventricle - بطن چهارمbiotinylated dextran amine - بیوترنیته دیستران آمینSpinal trigeminal tract - تریژمنیال ستون فقراتvesicular glutamate transporter - حمل و نقل گلوتامات vesiculartractus solitarius - دستگاه انفرادیSup - سوپmean arterial blood pressure - فشار خون شریانیBlood pressure - فشارخونartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیmap - نقشهparabrachial nucleus - هسته parabrachialmedial vestibular nucleus - هسته داخلی وادیnucleus of the solitary tract - هسته دستگاه انفرادیprepositus nucleus - هسته شهردارVestibular nucleus - هسته وستیبولارspinal vestibular nucleus - هسته ویستیبال ستون فقراتExternal lateral parabrachial nucleus - هسته پاراباژیال خارجی جانبی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Excitatory pathways from the vestibular nuclei to the NTS and the PBN and indirect vestibulo-cardiovascular pathway from the vestibular nuclei to the RVLM relayed by the NTS Excitatory pathways from the vestibular nuclei to the NTS and the PBN and indirect vestibulo-cardiovascular pathway from the vestibular nuclei to the RVLM relayed by the NTS](/preview/png/4328891.png)
چکیده انگلیسی
Previous studies have confirmed the existence of vestibulo-sympathetic pathways in the central nervous system. However, the exact pathways and neurotransmitters underlying this reflex are unclear. The present study was undertaken to investigate whether the vestibulo-cardiovascular responses are a result of activated glutamate receptors in the caudal vestibular nucleus. We also attempt to verify the indirect excitatory pathways from the vestibular nucleus (VN) to the rostral ventrolateral medulla (RVLM) using a tracing method combined with a vesicular glutamate transporter (VGluTs) immunofluorescence. In anesthetized rats, unilateral injection of l-glutamate (5 nmol) into the medial vestibular nucleus (MVe) and spinal vestibular nucleus (SpVe) slightly increased the mean arterial pressure (MVe: 93.29 ± 11.58 to 96.30 ± 11.66, SpVe: 91.72 ± 15.20 to 95.48 ± 17.16). Local pretreatment with the N-methyl-d-aspartate (NMDA)-receptor antagonist MK-801 (2 nmol) significantly attenuated the pressor effect of l-glutamate injected into the MVe compared to the contralateral self-control. After injection of biotinylated dextran amine (BDA) into the MVe and SpVe, and fluorogold (FG) into the RVLM, some BDA-labeled fibres and terminals in the nucleus of solitary tract (NTS) and the parabrachial nucleus (PBN) were immunoreactive for VGluT1 and VGluT2. Several BDA-labeled fibres were closely apposed to FG-labeled neurons in the NTS. These results suggested that activation of caudal vestibular nucleus neurons could induce pressor response and NMDA receptors might contribute to this response in the MVe. The glutamatergic VN-NTS and VN-PBN pathways might exist, and the projections from the VN to the RVLM relayed by the NTS comprise an indirect vestibulo-cardiovascular pathway in the brain stem.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1240, 13 November 2008, Pages 96-104
Journal: Brain Research - Volume 1240, 13 November 2008, Pages 96-104
نویسندگان
Yi-Ling Cai, Wen-Ling Ma, Jun-Qin Wang, Yi-Qian Li, Min Li,