کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4329710 | 1614222 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chronic electroconvulsive stimulation but not chronic restraint stress modulates mRNA expression of voltage-dependent potassium channels Kv7.2 and Kv11.1 in the rat piriform cortex
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کلمات کلیدی
ECTerg3ERG1KCNQ2PRLCA3CA1SSCECs - EC هاMHb - MHBAmygdala - آمیگدال، بادامهAMY - امیPir - بیش از حدelectroconvulsive stimulation - تحریک الکترو مغلوبSeizures - تشنجElectroconvulsive therapy - درمان با ضربه الکتریکی تشنجآور، الکتروشوک درمانیRoom temperature - دمای اتاقSaline Sodium Citrate - سدیم سدیم سدیمdentate gyrus - شکنج دندانه دارPyriform cortex - قشر پریمیرpiriform cortex - قشر پریکومprelimbic cortex - قشر پیش از قاعدگیmedial habenular nucleus - هسته عصب مرکزی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The mechanisms by which stress and electroconvulsive therapy exert opposite effects on the course of major depression are not known. Potential candidates might include the voltage-dependent potassium channels. Potassium channels play an important role in maintaining the resting membrane potential and controlling neuronal excitability. To explore this hypothesis, we examined the effects of one or several electroconvulsive stimulations and chronic restraint stress (6Â h/day for 21Â days) on the expression of voltage-dependent potassium channel Kv7.2, Kv11.1, and Kv11.3 mRNA in the rat brain using in situ hybridization. Repeated, but not acute, electroconvulsive stimulation increased Kv7.2 and Kv11.1 mRNA levels in the piriform cortex. In contrast, restraint stress had no significant effect on mRNA expression of Kv7.2, Kv11.1, or Kv11.3 in any of the brain regions examined. Thus, it appears that the investigated voltage-dependent potassium channels are not modulated by restraint stress at the level of mRNA expression. However, our findings suggest that repeated electroconvulsive stimulation alter Kv7.2 and Kv11.1 function in the piriform cortex, a finding with potential relevance for the chain of neurobiological events underlying the clinical effects of ECT.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1217, 27 June 2008, Pages 179-184
Journal: Brain Research - Volume 1217, 27 June 2008, Pages 179-184
نویسندگان
Marie-Louise Hjæresen, Ida Hageman, Gitta Wortwein, Per Plenge, Martin Balslev Jørgensen,