کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4330832 | 1614277 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dexamethasone enhances adenosine 5â²-triphosphate-sensitive potassium channel expression in the blood-brain tumor barrier in a rat brain tumor model
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Dexamethasone enhances adenosine 5â²-triphosphate-sensitive potassium channel expression in the blood-brain tumor barrier in a rat brain tumor model Dexamethasone enhances adenosine 5â²-triphosphate-sensitive potassium channel expression in the blood-brain tumor barrier in a rat brain tumor model](/preview/png/4330832.png)
چکیده انگلیسی
This study was performed to determine whether dexamethasone (DEX) had an effect on ATP-sensitive potassium channels (KATP channels) in blood-brain tumor barrier (BTB). Using a rat brain glioma model, we found that DEX could significantly increase the expression of KATP channels protein at tumor sites. And bradykinin-induced increase of KATP channels protein was further enhanced after DEX pretreatment for 3 consecutive days via Western blots and immunohistochemistry methods. In addition, DEX pretreatment enhanced bradykinin-mediated increase of the density of IKATP in the cultured rat C6 glioma cells using the patch-clamp technique in a whole-cell configuration. DEX significantly decreased the BTB permeability, but it did not reduce bradykinin-mediated BTB permeability increase, which were significantly attenuated by the KATP channel antagonist glibenclamide. This led to the conclusion that DEX-mediated change in BTB permeability is, at least partly, due to accelerated formation of KATP channel, an important target in the biochemical regulation of this process.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1162, 8 August 2007, Pages 1-8
Journal: Brain Research - Volume 1162, 8 August 2007, Pages 1-8
نویسندگان
Yan-ting Gu, Hua Zhang, Yi-xue Xue,