Keywords: کانال پتاسیم حساس به ATP; AM; adrenomedulin; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMY; amylin; AT; angiotensin type; β-CCT; beta-carboline-3-carboxylate-t-butyl ester; CT; calcitonin; CTR; calcitonin receptor; CLR; calcitonin receptor-like receptor; DZ; di
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Keywords: کانال پتاسیم حساس به ATP; 15-PGDH; 15-hydoxyprostaglandin dehydrogenase; AA; arachidonic acid; AF; atrial fibrillation; AKI; acute kidney injury; Akt; alpha serine/threonine-protein kinase; ALA; alpha-linolenic acid; AMD; age-related macular degeneration; Ang II; angiotensin II; B
Keywords: کانال پتاسیم حساس به ATP; ABCA1; ATP-binding cassette transporter; ACOG; American College of Obstetricians and Gynecologists; ACSM; American College of Exercise Medicine; AMPK; AMP-activate protein kinase; ADA; American Diabetes Association; BMI; body mass index; BMR; Basal metabo
Keywords: کانال پتاسیم حساس به ATP; Autonomic nervous system; Cardiac arrhythmias; Potassium channels; Acetylcholine-activated potassium channel; ATP-sensitive potassium channel; Atrial fibrillation;
Keywords: کانال پتاسیم حساس به ATP; 2,2-Dimethylchromans; ATP-Sensitive potassium channels; Potassium channel openers; Cromakalim analogs; Insulin secretion; Smooth muscle contractile activity; ADP; adenosine diphosphate; ATP; adenosine triphosphate; DCVC; dry column vacuum chromatography;
Mitochondria from rat uterine smooth muscle possess ATP-sensitive potassium channel
Keywords: کانال پتاسیم حساس به ATP; ATP-sensitive potassium channel; Diazoxide; 5-hydroxydecanoate; Myometrium; Mitochondria; Mitochondrial swelling; Mitochondrial membrane potential; ROS;
ATP-sensitive potassium-channel inhibitor glibenclamide attenuates HPA axis hyperactivity, depression- and anxiety-related symptoms in a rat model of Alzheimer's disease
Keywords: کانال پتاسیم حساس به ATP; Alzheimer disease; Aβ25-35; HPA axis; Glibenclamide; ATP-sensitive potassium channel;
The E23K variant of the Kir6.2 subunit of the ATP-sensitive potassium channel increases susceptibility to ventricular arrhythmia in response to ischemia in rats
Keywords: کانال پتاسیم حساس به ATP; ATP-sensitive potassium channel; E23K variant; Ventricular arrhythmia; Ischemia; Transgenic model;
Glyburide treatment in gestational diabetes is associated with increased placental glucose transporter 1 expression and higher birth weight
Keywords: کانال پتاسیم حساس به ATP; Glyburide; Placenta; Fetal growth; Pregnancy; Glucose transport; Syncytiotrophoblast; GDM; gestational diabetes mellitus; BMI; body mass index; KATP; ATP-sensitive potassium channel; MVM; microvillous plasma membrane; BM; basal plasma membrane; GLUT; gluc
Mitochondrial uncoupling in the melanocortin system differentially regulates NPY and POMC neurons to promote weight-loss
Keywords: کانال پتاسیم حساس به ATP; Mitochondrial uncoupling; NPY; POMC; Weight-loss; BAT thermogenesis; ATP-sensitive potassium channel;
Research PaperParadoxical lower sensitivity of Locus Coeruleus than Substantia Nigra pars compacta neurons to acute actions of rotenone
Keywords: کانال پتاسیم حساس به ATP; ACA; N-(p-amylcinnamoyl) anthranilic acid; DA; dopamine; DAergic; dopaminergic; FSCV; fast-scan cyclic voltammetry; KATP; ATP-sensitive potassium channel; LC; Locus Coeruleus; NA; noradrenaline; NAergic; noradrenergic; Non-DAergic; non-dopaminergic; PD; P
Mechanisms of the amplifying pathway of insulin secretion in the β cell
Keywords: کانال پتاسیم حساس به ATP; ABCC8; ATP binding cassette subfamily C member 8; ADCY5; adenylyl cyclase type 5; AICAR; 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside; DPP-IV; dipeptidyl peptidase 4; G6PD; glucose-6-phosphate dehydrogenase; GDH; glutamate dehydrogenase; GIP; gast
The effect of gliquidone on KATP channels in pancreatic β-cells, cardiomyocytes, and vascular smooth muscle cells
Keywords: کانال پتاسیم حساس به ATP; Gliquidone; ATP-sensitive potassium channel; Patch clamp technique; HIT-T15 cell; Cardiomyocyte; Vascular smooth muscle cell;
Role of ATP-sensitive potassium channels in modulating nociception in rat model of bone cancer pain
Keywords: کانال پتاسیم حساس به ATP; ATP-sensitive potassium channel; Bone cancer pain; Spinal cord; Allodynia; Pinacidil; Glibenclamide
Mechanisms underlying the development of the electrocardiographic and arrhythmic manifestations of early repolarization syndrome
Keywords: کانال پتاسیم حساس به ATP; ACh; acetylcholine; AP; action potential; BrS; Brugada syndrome; EDR; epicardial dispersion of repolarization; ER; early repolarization; ERS; early repolarization syndrome; ICa; calcium inward current; Ito; transient outward current; IVF; idiopathic ventr
Phosphatidylinositol 4,5-biphosphate (PIP2) modulates syntaxin-1A binding to sulfonylurea receptor 2A to regulate cardiac ATP-sensitive potassium (KATP) channels
Keywords: کانال پتاسیم حساس به ATP; PIP2; phosphatidylinositol 4,5-bisphosphate; KATP channels; ATP-sensitive K+ channels; SUR; sulfonylurea receptor; Syn-1A; syntaxin-1A; PM; plasma membrane; FRET; fluorescence resonance energy transfer; Kir; potassium inward rectifiers; PLC; phospholipase
ABCC9 is a novel Brugada and early repolarization syndrome susceptibility gene
Keywords: کانال پتاسیم حساس به ATP; Mutation; ATP-sensitive potassium channel; Sodium channel; Sudden cardiac death; J wave syndromes;
Anti-hyperalgesic effect of a benzilidine-cyclohexanone analogue on a mouse model of chronic constriction injury-induced neuropathic pain: Participation of the κ-opioid receptor and KATP
Keywords: کانال پتاسیم حساس به ATP; Neuropathic pain; Chronic constriction injury; Opioid receptor; Nitric oxide; Cyclic guanosine monophosphate; ATP-sensitive potassium channel;
Parametrisation of the free energy of ATP binding to wild-type and mutant Kir6.2 potassium channels
Keywords: کانال پتاسیم حساس به ATP; ATP-sensitive potassium channel; Kir6.2; Molecular dynamics; Homology modelling; Linear Interaction Energy (LIE) method;
Coronary spasm and acute myocardial infarction due to a mutation (V734I) in the nucleotide binding domain 1 of ABCC9
Keywords: کانال پتاسیم حساس به ATP; ATP-sensitive potassium channel; Kir6.x; SUR2; Coronary vasospasm; Myocardial infarction;
Reduced angiotensin II levels cause generalized vascular dysfunction via oxidant stress in hamster cheek pouch arterioles
Keywords: کانال پتاسیم حساس به ATP; ACE; angiotensin converting enzyme; ACh; acetylcholine; ANG II; angiotensin II; ARB; angiotensin receptor blocker; AT1; angiotensin II type 1 receptor; cGMP; cyclic guanosine monophosphate; Cu/Zn SOD; copper zinc (intracellular) superoxide dismutase; DHE;
KATP channels of parafacial respiratory group (pFRG) neurons are involved in H2S-mediated central inhibition of respiratory rhythm in medullary slices of neonatal rats
Keywords: کانال پتاسیم حساس به ATP; Hydrogen sulfide; Respiratory rhythm; ATP-sensitive potassium channel; Parafacial respiratory group; Medullary slice
Minoxidil sulfate induced the increase in blood–brain tumor barrier permeability through ROS/RhoA/PI3K/PKB signaling pathway
Keywords: کانال پتاسیم حساس به ATP; Blood–tumor barrier; ATP-sensitive potassium channel; Glioma; Reactive oxygen species; Tight junction protein
Synthesis and pharmacological activity of N-(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides on rat uterus, rat aorta and rat pancreatic β-cells
Keywords: کانال پتاسیم حساس به ATP; Benzothiadiazine dioxides; Benzopyranes; Hybrid compounds; Myorelaxant activity; Insulin secretion; Tissue selectivity; KATP channel; ATP-sensitive potassium channel; NMR; nuclear magnetic resonance; DMSO; dimethylsulfoxide; HMDS; hexamethyldisiloxane;
Properties and functions of KATP during mouse perinatal development
Keywords: کانال پتاسیم حساس به ATP; Cardiogenesis; ATP-sensitive potassium channel; Mouse embryo; Acute hypoxia-ischemia; APD90;
Molecular genetic and functional association of Brugada and early repolarization syndromes with S422L missense mutation in KCNJ8
Keywords: کانال پتاسیم حساس به ATP; ATP-sensitive potassium channel; Electrophysiology; Hotspot mutation; J-wave syndrome; Short QT; Sudden cardiac death; Ventricular TachycardiaAP, action potential; ATP, adenosine triphosphate; BrS, Brugada syndrome; ECG, electrocardiogram; ER, early repol
N-Aryl-Nâ²-(chroman-4-yl)ureas and thioureas display in vitro anticancer activity and selectivity on apoptosis-resistant glioblastoma cells: Screening, synthesis of simplified derivatives, and structure-activity relationship analysis
Keywords: کانال پتاسیم حساس به ATP; Apoptosis-resistant glioblastoma cells; Chromans; Antitumor agents; Potassium channel openers; Computer-assisted quantitative videomicroscopy; GBM; glioblastoma; ATP; adenosine triphosphate; SUR; sulfonylurea receptor; Kir channel; potassium inwardly rect
Reduction in number of sarcolemmal KATP channels slows cardiac action potential duration shortening under hypoxia
Keywords: کانال پتاسیم حساس به ATP; ATP-sensitive potassium channel; KATP; Heart; Glyburide; Monophasic action potential
Research ReportAIF-mediated mitochondrial pathway is critical for the protective effect of diazoxide against SH-SY5Y cell apoptosis
Keywords: کانال پتاسیم حساس به ATP; Diazoxide; Oxygen and glucose deprivation; Apoptosis; Apoptosis-inducing factor; Mitochondria; OGD; oxygen and glucose deprivation; 5-HD; 5-hydroxydecanoic acid; AIF; apoptosis-inducing factor; KATP; ATP-sensitive potassium channel; mitoKATP; mitochondria
Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts
Keywords: کانال پتاسیم حساس به ATP; AFL/AF; atrial flutter and fibrillation; AP; action potential; APD; action potential duration; BCL; basic cycle length; KATP; ATP-sensitive potassium channel; CHF; heart with congestive heart failure; DF; dominant frequency; NF; heart without CHF; INF; he
Cross talk between mitochondria and NADPH oxidases
Keywords: کانال پتاسیم حساس به ATP; Mitochondria; NADPH oxidase; Superoxide; Mitochondria-targeted antioxidant; ATP-sensitive potassium channel; Feed-forward regulation; Free radicals;
Syntaxin-1A inhibits KATP channels by interacting with specific conserved motifs within sulfonylurea receptor 2A
Keywords: کانال پتاسیم حساس به ATP; Syntaxin-1A; SNARE; ATP-sensitive potassium channel; SUR2A; Kir6.2
ATP-sensitive potassium channels contribute to the time-dependent alteration in the pentylenetetrazole-induced seizure threshold in diabetic mice
Keywords: کانال پتاسیم حساس به ATP; Diabetes mellitus; Seizure; ATP-sensitive potassium channel; Pentylenetetrazole; Clonic seizure threshold; Mice
Anti-ischemic properties of a new spiro-cyclic benzopyran activator of the cardiac mito-KATP channel
Keywords: کانال پتاسیم حساس به ATP; CsA; cyclosporine A; 5-HD; 5-hydroxydecanoic acid; IPC; ischemic pre-conditioning; I/R; ischemia/reperfusion; LAD; left anterior descending coronary artery; KATP; ATP-sensitive potassium channel; MPTP; mitochondrial permeability transition pore; Myocardia
Roles of phospho-GSK-3β in myocardial protection afforded by activation of the mitochondrial KATP channel
Keywords: کانال پتاسیم حساس به ATP; Glycogen synthase kinase-3Ã; Mitochondria; ATP-sensitive potassium channel; Infarct size; Reperfusion injury;
Target site occupancy: Emerging generalizations from clinical and preclinical studies
Keywords: کانال پتاسیم حساس به ATP; Target site occupancy; Receptor reserve; Positron Emission Tomography; Single Photon Emission Computed Tomography; G protein-coupled receptor; Target biomarker; BZD; benzodiazepine; CNS; central nervous system; DAT; dopamine transporter; EEDQ; N-ethoxycar
Modafinil modulates GABA-activated currents in rat hippocampal pyramidal neurons
Keywords: کانال پتاسیم حساس به ATP; GABA; γ-aminobutyric acid; IGABA; GABA-activated currents; KATP; ATP-sensitive potassium channel; Bic; bicuculline; MPTP; 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine; Gli; glibenclamide; Moda; modafinil; Modafinil; γ-aminobutyric acid; KATP channel; Hip
The endogenous mitochondrial complex II inhibitor malonate regulates mitochondrial ATP-sensitive potassium channels: Implications for ischemic preconditioning
Keywords: کانال پتاسیم حساس به ATP; ATP-sensitive potassium channel; mKATP; Preconditioning; Ischemia; Succinate dehydrogenase; Diazoxide; Mitochondria;
Inhibition of striatal dopamine release by CB1 receptor activation requires nonsynaptic communication involving GABA, H2O2, and KATP channels
Keywords: کانال پتاسیم حساس به ATP; CB1 receptor; Dopamine; Striatum; Volume transmission; Hydrogen peroxide; ATP-sensitive potassium channel; Brain slices;
Role of ATP-sensitive potassium channels in the biphasic effects of morphine on pentylenetetrazole-induced seizure threshold in mice
Keywords: کانال پتاسیم حساس به ATP; Morphine; ATP-sensitive potassium channel; Pentylentetrazole; Clonic seizure threshold; Mice
Evidence for functional ATP-sensitive (KATP) potassium channels in human and equine articular chondrocytes
Keywords: کانال پتاسیم حساس به ATP; Cartilage; Osteoarthritis; Chondrocyte; ATP-sensitive potassium channel; KATP, Kir6.1, Ion channel; Immunohistochemistry
Dexamethasone enhances adenosine 5â²-triphosphate-sensitive potassium channel expression in the blood-brain tumor barrier in a rat brain tumor model
Keywords: کانال پتاسیم حساس به ATP; Dexamethasone; Bradykinin; Blood-tumor barrier; Blood-brain barrier; ATP-sensitive potassium channel; Glioma;
ATP-sensitive potassium channels expressed by human monocytes play a role in stasis-induced thrombogenesis via tissue factor pathway
Keywords: کانال پتاسیم حساس به ATP; Hemostasis; Blood flow; Thrombosis; Clotting; Monocytes; Hypoxia; Hypoglycemia; ATP-sensitive potassium channel; Glibenclamide; LPS; Tissue factor; Phospholipids; Phospatidylserine
Uncoupling by (−)-epigallocatechin-3-gallate of ATP-sensitive potassium channels from phosphatidylinositol polyphosphates and ATP
Keywords: کانال پتاسیم حساس به ATP; Epicatechin; ATP-sensitive potassium channel; Phosphatidylinositol polyphosphate; Insulin secretion; Cardiomyocyte
Effects of iptakalim on extracellular glutamate and dopamine levels in the striatum of unilateral 6-hydroxydopamine-lesioned rats: A microdialysis study
Keywords: کانال پتاسیم حساس به ATP; ATP-sensitive potassium channel; Iptakalim; Unilateral 6-OHDA-lesioned rats; Extracellular glutamate; Extracellular dopamine
Effects of KR-31378, a novel ATP-sensitive potassium channel activator, on hypertrophy of H9c2 cells and on cardiac dysfunction in rats with congestive heart failure
Keywords: کانال پتاسیم حساس به ATP; Cell hypertrophy; Congestive heart failure; KR-31378; Myocardial infarction; ATP-sensitive potassium channel
Increased ATP-sensitive K+ channel expression during acute glucose deprivation
Keywords: کانال پتاسیم حساس به ATP; ATP-sensitive potassium channel; KATP channels; Insulin secretion; AMP-activated protein kinase; AMPK; Glucose sensing; Glucose-stimulated insulin secretion
Large-conductance, calcium-activated potassium channels: Structural and functional implications
Keywords: کانال پتاسیم حساس به ATP; BK; large-conductance, calcium-activated potassium channel; Ca2+; calcium; ChTX; charybdotoxin; CICR; Ca2+-induced Ca2+ release; CO; carbon monoxide; DHS-1; dehydrosoyasaponin-1; EETs; epoxyeicosatrienoic acids; GPTX; pertussis toxin-sensitive G-proteins;
Cortical spreading depression (CSD)-induced tolerance to transient focal cerebral ischemia in halothane anesthetized rats is affected by anesthetic level but not ATP-sensitive potassium channels
Keywords: کانال پتاسیم حساس به ATP; Diseases of the nervous system; Ischemia; Preconditioning; ATP-sensitive potassium channel; Stroke; Adenosine receptor; Nitric oxide; Cerebral cortex;
Acidosis-induced relaxation of human internal mammary artery is due to activation of ATP-sensitive potassium channels
Keywords: کانال پتاسیم حساس به ATP; Acidosis; ATP-sensitive potassium channel; Human internal mammary artery; pH; Vascular smooth muscle;