کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4329774 1614231 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Modafinil modulates GABA-activated currents in rat hippocampal pyramidal neurons
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Modafinil modulates GABA-activated currents in rat hippocampal pyramidal neurons
چکیده انگلیسی
Modafinil is a well-known psychoactive drug used to treat narcolepsy, hypoglycemia, cerebral ischemia and Parkinson's disease. Previous studies showed that ATP-sensitive potassium channels (KATP) play a key role in response to cerebral ischemia, hypoglycemia or metabolic inhibition. Modafinil (0.01-1 mM) dose-dependently decreased the GABA-activated currents (IGABA). Pretreatment with the KATP channel blocker, glibenclamide (10 μM), significantly reduced the decrease of IGABA caused by modafinil. Thus, the inhibitory effect of modafinil on the IGABA is indirect by modulating KATP channel activation, at least in part mediated by KATP channel.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1208, 7 May 2008, Pages 74-78
نویسندگان
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