Roles of phospho-GSK-3β in myocardial protection afforded by activation of the mitochondrial KATP channel

►Activation of the mKATP channel is not sufficient for GSK-3β phosphorylation. ►In that GSK-3β phosphorylation, PKC-ε, PI3K and A2b receptor are involved. ►Phospho-GSK-3β contributes to cardioprotection by mKATP channel activation. ►Cyclophilin-D binding to ANT is inhibited by activation of the mKATP channel.