Properties and functions of KATP during mouse perinatal development

► SarcKATP current density remained constant during development. ► Developmental changes were found in sarcKATP subunits but not in mitoKATP. ► EDS cardiomyocytes were more sensitive to acute hypoxia-ischemia than LDS cells. ► SarcKATP played distinct functional roles under acute hypoxia-ischemic condition. ► MitoKATP were not involved in the response to acute hypoxia-ischemia.