Keywords: APD90; action potential duration measured at 90% repolarization; ICa,L; calcium activated current via L-channel; INa; sodium activated current; IKr; rapidly activating delayed rectifier potassium current; IKs; slowly activating delayer rectifier potassium
مقالات ISI (ترجمه نشده)
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Keywords: AP; action potential; APD; action potential duration; APD30; APD at 30% repolarization; APD90; APD at 90% repolarization; APD30-90; APD90-APD30; [Ca2Â +]i; intracellular Ca2Â + concentration; CiPA; Comprehensive in vitro Proarrhythmia Assay; CV; condu
Keywords: Nifedipine (PubChem CID: 4485); E4031 (PubChem CID: 3185); Dofetilide (PubChem CID: 71329); Lidocaine (PubChem CID: 3676); ZD7288 (PubChem CID: 123983); Verapamil (PubChem CID: 2520); Azimilide (PubChem CID: 9571004); Ranolazine (PubChem CID: 56959); Tert
Keywords: Action potential; Atrium; Heart; Interleukin 2; Stretch; APs; action potentials; APA; action potential amplitude; APD25; action potential durations to 25% of repolarization; APD90; action potential durations to 50% of repolarization (APD50) and action pot
Keywords: APD; action potential duration; ÎÎ-APD; drug effect on APD compared to control; APD90; 90% action potential duration; AAP; amplitude of the action potential; Vrest; resting membrane potential; IKr; rapid component of delayed rectifier potassium current;
Keywords: AP; action potential; APD50; AP duration at 50% repolarization; APD90; AP duration at 90% repolarization; IKATP; ATP-sensitive K+ current; CaMKII; Ca2Â +-calmodulin-dependent kinase II; DHP receptors; 1,4-dihydropyridine receptors; EC-coupling; excitation
Keywords: Ac-H3; acetyl-Histone H3; AF; atrial fibrillation; AP; action potential; APD50; action potential duration at 50% repolarization; APD90; action potential duration at 90% repolarization; Ca2Â +i; intracellular calcium; CaMKII; Calmodulin-dependent protein k
Keywords: AF; atrial fibrillation; AMI; acute myocardial ischemia; AP; action potential; APD; action potential duration; APD90; an APD at 90% repolarization; CV; coefficient of variation; DI; diastolic interval; ERP; effective refractory period; GP; ganglionated pl
Keywords: APD90; action potential duration at 90% repolarization; BDM; 2,3-butanedione monoxime; BTS; N-benzyl-p-toluene sulphonamide; Cav1.2; calcium channel produced from the CACNA1C gene; cTnI; cardiac troponin I; C-E curve; concentration-effect curve; Cx43; con
Optogenetic Modulation of Cardiac Sympathetic Nerve Activity to Prevent Ventricular Arrhythmias
Keywords: left stellate ganglion neural silencing; optogenetics; ventricular arrhythmia; AAV; adeno-associated virus; APD; action potential duration; APD90; 90% repolarization duration; BP; blood pressure; ECG; electrocardiography; ERP; effective refractory period;
Sarcolemmal Ca2+-entry through L-type Ca2+ channels controls the profile of Ca2+-activated Clâ current in canine ventricular myocytes
Keywords: 9-AC; 9-anthracene carboxylic acid; AP; action potential; APVC; action potential voltage-clamp; APD90; action potential duration at 90% of repolarization; BKCa; large-conductance Ca2+-activated K+ channels; CaT; calcium transient; Cav1.2; pore forming sub
In silico assessment of kinetics and state dependent binding properties of drugs causing acquired LQTS
Keywords: Acquired long QT syndrome; Kinetics; Kv11.1; Arrhythmia; Simulation; hERG; IKr; rapid delayed rectifier potassium current; AP; action potential; APD90; action potential duration at 90% maximal repolarisation; IKr50; 50% reduction in conductance of the rap
Polygenic case of long QT syndrome confirmed through functional characterization informs the interpretation of genetic screening results
Keywords: APD; action potential duration; APD90; action potential duration at 90% repolarization; ECG; electrocardiogram; HEK; human embryonic kidney; LQT; long QT; LQTS; long QT syndrome; LQT(2-3); long QT syndrome type (2-3); VUS; variant of unknown significance;
In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome
Keywords: aLQTS; drug-induced or acquired long-QT syndrome; AP; action potential; APD; action potential duration; APD90; action potential duration at 90% repolarization; C1; closed state 1; C2; closed state 2; C3; closed state 3; EAD; early-afterdepolarization; ECG
Selective activation of heteromeric SK channels contributes to action potential repolarization in mouse atrial myocytes
Keywords: AF; atrial fibrillation; AP; action potential; APD; action potential duration; APD90; action potential duration at 90% repolarization; BVR; beat-to-beat variability in repolarization; EGTA; ethylene glycol-bis(2-aminoethylether)-N,N,Nâ²,Nâ²-tetraacetic
The variant hERG/R148W associated with LQTS is a mutation that reduces current density on co-expression with the WT
Keywords: APD; Action potential duration; APD90; APD at 90% repolarization; DNA; Deoxyribonucleic acid; cDNA; Cyclic DNA; ECG; Electrocardiogram; ESP; Exome Sequencing Project; HEK293; Human-derived renal epithelial cell line number 293; hERG; Human ether-Ã -go-go
A KCNQ1 mutation contributes to the concealed type 1 long QT phenotype by limiting the Kv7.1 channel conformational changes associated with protein kinase A phosphorylation
Keywords: AKAP9; A-kinase anchoring protein 9 (Yotiao); AP; action potential; APD90; steady-state action potential duration at 90% repolarization; ECG; electrocardiogram/electrocardiographic; HEK293; human embryonic kidney 293; IKs; slowly activating delayed rectif
In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome
Keywords: aLQTS; drug-induced or acquired long-QT syndrome; AP; action potential; APD; action potential duration; APD90; action potential duration at 90% repolarization; C1; closed state 1; C2; closed state 2; C3; closed state 3; EAD; early-afterdepolarization; ECG
Human embryonic stem cell derived cardiac myocytes detect hERG-mediated repolarization effects, but not Nav1.5 induced depolarization delay
Keywords: Human embryonic stem cells derived cardiac myocytes; Isolated rabbit heart; Patch-clamp method; APD90; QRS intervals; QTc intervals;
Properties and functions of KATP during mouse perinatal development
Keywords: Cardiogenesis; ATP-sensitive potassium channel; Mouse embryo; Acute hypoxia-ischemia; APD90;
A novel method of selecting human embryonic stem cell-derived cardiomyocyte clusters for assessment of potential to influence QT interval
Keywords: APD; action potential duration; APD90; action potential duration at 90% repolarization; (±)-Bay K8644; methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate; bpm; beats per minute; chro-manol 293B; N-[(3R,4S)-6-cyano
Lysophosphatidylcholine enhances IKs currents in cardiac myocytes through activation of G protein, PKC and Rho signaling pathways
Keywords: LPC; lysophosphatidylcholine; LPC-16; 1-palmitoyl-lysophosphatidylcholine; LPC-6; 1-caproyl-lysophosphatidylcholine; LPC-18:1; 1-oleoyl-lysophosphatidylcholine; PC; phosphatidylcholine; SPC; sphingosylphosphorylcholine; IKs; slow activating component of d
Cell to bedsideCardiac Purkinje cells
Keywords: Arrhythmia; Calcium; Ion channel; Pacemaker activity; Purkinje cell; AP; action potential; APD90; action potential duration at 90% repolarization; AV; atrioventricular; DAD; delayed afterdepolarization; EAD; early afterdepolarization; IZPC; Purkinje cell
Torsades de pointes liability inter-model comparisons: The experience of the QT PRODACT initiative
Keywords: APD; action potential duration; APD90; APD at 90% repolarization; APD30-90; APD between 30% and 90% repolarization; APD30-60; APD between 30% and 60% repolarization; AV; atrioventricular; EC10; effective concentration producing 10% changes; IKr; rapid
Atrial proarrhythmia due to increased inward rectifier current (IK1) arising from KCNJ2 mutation - A simulation study
Keywords: Arrhythmia; Sudden death; Ion channels; Fibrillation atrial; Gene mutation; Channelopathy; Inward rectifier; IK1; Potassium channel; Ît; time delay; 1D, 2D, 3D; one-, two- and three-dimensional model; AF; atrial fibrillation; AP; action potential; APD; a
Additive effects of ziprasidone and d,l-sotalol on the action potential in rabbit Purkinje fibres and on the hERG potassium current
Keywords: Action potential; Additive effects; APD90; d,l-sotalol; HEK-293 cells; hERG current; Interaction; Methods; Rabbit Purkinje fibres; Ziprasidone;
Nonclinical proarrhythmia models: Predicting Torsades de Pointes
Keywords: AP; Action potential; APD; Action potential duration; APD90; Action potential duration at 90% repolarization; A-V; Atrioventricular; CAVB; Chronically A-V block; CV; Conduction velocity; EADs; Early after-depolarizations; ECG; Electrocardiogram; hERG; Hum