کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8474299 | 1550422 | 2015 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
How cardiomyocyte excitation, calcium release and contraction become altered with age
ترجمه فارسی عنوان
چگونه تحریک کراتومیوسیت، انتشار کلسیم و انقباض با سن تغییر می کند
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
چکیده انگلیسی
Cardiovascular disease is the main cause of death globally, accounting for over 17 million deaths each year. As the incidence of cardiovascular disease rises markedly with age, the overall risk of cardiovascular disease is expected to increase dramatically with the aging of the population such that by 2030 it could account for over 23 million deaths per year. It is therefore vitally important to understand how the heart remodels in response to normal aging for at least two reasons: i) to understand why the aged heart is increasingly susceptible to disease; and ii) since it may be possible to modify treatment of disease in older adults if the underlying substrate upon which the disease first develops is fully understood. It is well known that age modulates cardiac function at the level of the individual cardiomyocyte. Generally, in males, aging reduces cell shortening, which is associated with a decrease in the amplitude of the systolic Ca2Â + transient. This may arise due to a decrease in peak L-type Ca2Â + current. Sarcoplasmic reticulum (SR) Ca2Â + load appears to be maintained during normal aging but evidence suggests that SR function is disrupted, such that the rate of sarco/endoplasmic reticulum Ca2Â +-ATPase (SERCA)-mediated Ca2Â + removal is reduced and the properties of SR Ca2Â + release in terms of Ca2Â + sparks are altered. Interestingly, Ca2Â + handling is modulated by age to a lesser degree in females. Here we review how cellular contraction is altered as a result of the aging process by considering expression levels and functional properties of key proteins involved in controlling intracellular Ca2Â +. We consider how changes in both electrical properties and intracellular Ca2Â + handling may interact to modulate cardiomyocyte contraction. We also reflect on why cardiovascular risk may differ between the sexes by highlighting sex-specific variation in the age-associated remodeling process. This article is part of a Special Issue entitled CV Aging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular and Cellular Cardiology - Volume 83, June 2015, Pages 62-72
Journal: Journal of Molecular and Cellular Cardiology - Volume 83, June 2015, Pages 62-72
نویسندگان
Hirad A. Feridooni, Katharine M. Dibb, Susan E. Howlett,