کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4330962 | 1614283 | 2007 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Brain stimulation reward is integrated by a network of electrically coupled GABA neurons
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کلمات کلیدی
MFBBSRGADNAccBDAglutamic acid decarboxylase - glutamic acid dearboxylasePSH - PAgamma-aminobutyric acid - اسید گاما آمینو بوتیریکImmunoreactivity - ایمنی فعالmedial forebrain bundle - بسته نرم افزاری پروبیالbiotinylated dextran amine - بیوترنیته دیستران آمینDopamine - دوپامینgap junction - فاصله ی شکافfluorescent in situ hybridization - فلورسنت در محل hybridizationFish - ماهیNucleus accumbens - هسته accumbenslateral hypothalamus - هیپوتالاموس جانبیbrain stimulation reward - پاداش تحریک مغزconnexin - کنسکسینinternal capsule - کپسول داخلیGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Brain stimulation reward is integrated by a network of electrically coupled GABA neurons Brain stimulation reward is integrated by a network of electrically coupled GABA neurons](/preview/png/4330962.png)
چکیده انگلیسی
The neural substrate of brain stimulation reward (BSR) has eluded identification since its discovery more than a half-century ago. Notwithstanding the difficulties in identifying the neuronal integrator of BSR, the mesocorticolimbic dopamine (DA) system originating in the ventral tegmental area (VTA) of the midbrain has been implicated. We have previously demonstrated that the firing rate of a subpopulation of γ-aminobutyric acid (GABA) neurons in the VTA increases in anticipation of BSR. We show here that GABA neurons in the VTA, midbrain, hypothalamus, and thalamus of rats express connexin-36 (Cx36) gap junctions (GJs) and couple electrically upon DA application or by stimulation of the internal capsule (IC), which also supports self-stimulation. The threshold for responding for IC self-stimulation was the threshold for electrical coupling between GABA neurons, the degree of responding for IC self-stimulation was proportional to the magnitude of electrical coupling between GABA neurons, and GJ blockers increased the threshold for IC self-stimulation without affecting performance. Thus, a network of electrically coupled GABA neurons in the ventral brain may form the elusive neural integrator of BSR.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1156, 2 July 2007, Pages 46-58
Journal: Brain Research - Volume 1156, 2 July 2007, Pages 46-58
نویسندگان
Matthew B. Lassen, J. Elliott Brown, Sarah H. Stobbs, Seth H. Gunderson, Levi Maes, C. Fernando Valenzuela, Andrew P. Ray, Steven J. Henriksen, Scott C. Steffensen,