کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4331059 1614285 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Minocycline, a second-generation tetracycline, as a neuroprotective agent in an animal model of schizophrenia
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Minocycline, a second-generation tetracycline, as a neuroprotective agent in an animal model of schizophrenia
چکیده انگلیسی

Minocycline is a second-generation tetracycline with a distinct neuroprotective profile. The current study assessed the effects of minocycline in an animal model of schizophrenia, the non-competitive NMDA antagonist (dizocilpine maleate; MK801). The effects of minocycline were compared to those of haloperidol, a dopamine antagonist used for the treatment of schizophrenia. The study protocol involved daily intraperitoneal injections of minocycline (35 mg/kg) for three consecutive days. On the fourth day, the rats were injected with MK801 and assessed for visual–spatial memory (Morris water maze) and sensorimotor gating (acoustic startle response, ASR, and the prepulse inhibition of the ASR). The findings indicate that MK801 caused cognitive visuo-spatial memory deficits and changes in sensorimotor gating, similar to those evident in schizophrenia. Minocycline reversed these cognitive effects of MK801 and this effect was similar to that of haloperidol. The results of this study suggest that minocycline may have protective properties against the cognitive effects of the MK801 animal model of schizophrenia. The discussion addresses potential mechanisms underlying the effects of minocycline and possible directions for future research.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1154, 18 June 2007, Pages 154–162
نویسندگان
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