کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4331094 | 1614286 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Therapeutic effects of hyperbaric oxygen in a rat model of endothelin-1-induced focal cerebral ischemia
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
ET-1polyvinylideneatmosphere absoluteATABNIP3HIF-1αHbOMCAOBcl-2MCAPBSendothelin - اندوتلینendothelin-1 - اندوتلین-1middle cerebral artery occlusion - انسداد شریان (سرخرگ) مغزی میانیHyperbaric oxygen - اکسیژن بیش از حدFocal cerebral ischemia - ایسکمی مغز مرکزی کانونیBax - باکسanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancemiddle cerebral artery - شریان مغزی میانیhypoxia-inducible factor-1α - عامل القاء شده با هیپوکسی 1αPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافری
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
It has been established that hyperbaric oxygen (HBO) treatment reduces brain edema, decreases infarct volume, contributes to neurological functional recovery and suppresses apoptosis in suture-induced focal cerebral ischemic animal models. In the present study, we evaluated the therapeutic effect of HBO in an endothelin-1-induced focal cerebral ischemia in rats and explored the associated mechanisms of HBO-induced brain protection. One hundred twenty male Sprague-Dawley rats (280 to 320 g) were randomly assigned to sham, focal cerebral ischemia and focal cerebral ischemia treated with HBO groups. Brain water content, neurological function, morphology and molecular biological markers were assessed. HBO (100% O2, 2.5 atmosphere absolute for 2 h) was initiated at 1 h after focal cerebral ischemia. Rats were killed at 24 h to harvest tissues for Western blot or for histology. In HBO-treated animals, an enhanced ratio of Bcl-2 and Bax and a reduced expression of hypoxia-inducible factor-1α (HIF-1α) in the hippocampus after focal cerebral ischemia were observed. These results indicate that HBO provides brain protection that is probably associated with the inhibition of HIF-1α and the elevation of Bcl-2.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1153, 11 June 2007, Pages 204-213
Journal: Brain Research - Volume 1153, 11 June 2007, Pages 204-213
نویسندگان
Zhen-Xing Huang, Zhi-Min Kang, Guo-Jun Gu, Guang-Neng Peng, Liu Yun, Heng-Yi Tao, Wei-Gang Xu, Xue-Jun Sun, John H. Zhang,