کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4331327 | 1614291 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of photoreceptor degeneration on circadian photoreception and free-running period in the Royal College of Surgeons rat
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
The study of how the retina processes the photic information required for the entrainment of the circadian system is an exciting new topic in retinal neurobiology. We have recently shown that in RCS/N-rdy rats melanopsin mRNA levels are dramatically reduced (about 90%) and melanopsin immunoreactivity cannot be detected in the retina of these rats at 60 days of age. Although RCS/N-rdy rats are a widely used model to investigate mechanisms of photoreceptor degeneration, no study has investigated circadian photoreception in these animals. The aim of this study was to examine circadian photoreception in RCS/N-rdy+ (rdy+) rats homozygous for the normal rdy allele and age-matched RCS/N-rdy (rdy) homozygotes with retinal dystrophy. No differences between RCS/N-rdy and rdy+ were observed in light-induced phase shift of locomotor activity at the three light intensities used (1 Ã 10â 3, 1 Ã 10â 1, and 1 Ã 101 μW cmâ 2). Surprisingly, we observed that in RCS/N-rdy the free-running period of the circadian rhythm of locomotor activity was shorter (P < 0.01) than in rdy+, thus suggesting that photoreceptor degeneration may affect the free-running period of the locomotor activity rhythm.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1148, 7 May 2007, Pages 76-82
Journal: Brain Research - Volume 1148, 7 May 2007, Pages 76-82
نویسندگان
Gianluca Tosini, Jacopo Aguzzi, Nicole M. Bullock, Cuimei Liu, Manami Kasamatsu,