کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4332036 | 1292885 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of melatonin on synaptic transmission and long-term potentiation in two areas of mouse hippocampus
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of melatonin on synaptic transmission and long-term potentiation in two areas of mouse hippocampus Effects of melatonin on synaptic transmission and long-term potentiation in two areas of mouse hippocampus](/preview/png/4332036.png)
چکیده انگلیسی
We have examined the effects of melatonin on synaptic transmission and long-term potentiation (LTP) in the Schaffer Collateral–CA1 and the mossy fiber–CA3 pathways in mouse hippocampus brain slices. Melatonin (0.1–1 mM) application had different actions on both the field excitatory postsynaptic potentials (fEPSPS) and LTP in the CA1 as compared to the CA3. In CA1, 0.1 mM melatonin blocked LTP, while 1 mM melatonin also depressed the fEPSP. In CA3, neither 0.1 nor 1 mM melatonin altered the fEPSP, whereas both concentrations only slightly reduced LTP. These results demonstrate that melatonin significantly alters synaptic transmission and LTP in the CA1 but has only modest actions in CA3.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1111, Issue 1, 21 September 2006, Pages 90–94
Journal: Brain Research - Volume 1111, Issue 1, 21 September 2006, Pages 90–94
نویسندگان
Mete Ozcan, Bayram Yilmaz, David O. Carpenter,