کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4332394 | 1292896 | 2006 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Enhancement of neuroprotection and heat shock protein induction by combined prostaglandin A1 and lithium in rodent models of focal ischemia
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
growth arrest and DNA damage-inducible geneICAECAPGA1CCAGADDHspProstaglandin A1GADD153GRPpMCAOLithium - لیتیمC/EBP homologous protein - C / EBP پروتئین همولوگPermanent middle cerebral artery occlusion - انسداد شریان مغزی میانی دائمیCerebral ischemia - ایسکمی مغزیCHOP - تکه کردنexternal carotid artery - شریان کاروتید خارجیinternal carotid artery - شریان کاروتید داخلیcommon carotid artery - شریان کاروتید مشترکNeuroprotection - محافظت نورونی یا محافظت از عصبglucose-regulated protein - پروتئین تنظیم شده با گلوکزHeat shock protein - پروتئین شوک حرارت
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Both prostaglandin A1 (PGA1) and lithium have been reported to protect neurons against excitotoxic and ischemic injury. The present study was undertaken to examine the effects of lithium and PGA1 on heat shock proteins (HSP) and the growth arrest and DNA-damage-inducible gene (GADD153) and to evaluate if lithium could potentiate PGA1's neuroprotective effects against cerebral ischemia. Rats were pretreated with a subcutaneous injection of lithium for 2Â days and a single intracerebral ventricle administration of PGA1 15Â min before ischemic insult. Brain ischemia was induced by a permanent middle cerebral artery occlusion. The infarct volume, motor behavior deficits and brain edema were analyzed 24Â h after ischemic insult. The result showed that PGA1 significantly reduced infarct volume, neurological deficits and brain edema. Except for neurological deficit, lithium enhanced PGA1's neuroprotection. The neuroprotective effects of PGA1 were associated with an up-regulation of cytoprotective heat shock proteins HSP70 and GRP78 in the ischemic brain hemisphere as determined by immunoblotting and immunofluorescence. The induction of HSP70 and GRP78 was enhanced by lithium. However, although the expression of GADD153 was enhanced significantly after pMCAO, it was not influenced by either PGA1 or lithium or their combination. These studies suggest that lithium can potentiate PGA1's neuroprotective effects and thus may have potential clinical value for the treatment of stroke in combination with other neuroprotective agents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1102, Issue 1, 2 August 2006, Pages 154-162
Journal: Brain Research - Volume 1102, Issue 1, 2 August 2006, Pages 154-162
نویسندگان
Xi-Hui Xu, Hui-Lin Zhang, Rong Han, Zhen-Lun Gu, Zheng-Hong Qin,