کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4332556 | 1292903 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Growing axons in fish optic nerve are accompanied by astrocytes interconnected by tight junctions
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کلمات کلیدی
GFAPAQP4Aquaporin-4OSPZO-1OAPSOrthogonal arrays of particles - آرایه ای از ذراتLSM - سازمان غیر دولتیBBB - سد خونی مغزیBlood–brain barrier - سد خونی مغزیAstatotilapia burtoni - سپیده دم از باپتیستLaser scanning microscope - میکروسکوپ اسکن لیزرGlial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایالclaudin - کلودینGlia - یاختههای گلیال
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Mammalian astrocytes are in general interconnected by gap but not by tight junctions and play an ambiguous and controversially discussed role in central nervous system regeneration. At different neuroanatomical sites, fish astrocytes are interconnected by tight junctions and desmosomes and are involved in the successful regeneration of lesioned fiber tracts. In fish, newly generated retinal ganglion cells continuously grow new axons to the optic tectum but the interrelationship between glial tight junctions and axonal growth is undefined so far. We therefore investigated the occurrence of tight junctional structures and molecules within the ribbon-shaped optic nerve of a teleost fish (Astatotilapia burtoni) and found a predominant expression of zonula occludens protein-1 and claudin-1 in astrocytes where axons of new ganglion cells are assembled retinotopically within the optic nerve. This may support a previously formulated hypothesis according to that different properties of astrocytic membranes could be responsible for different glio-neuronal interactions which in turn may determine the micro-environmental conditions of growing axons.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1103, Issue 1, 4 August 2006, Pages 25-31
Journal: Brain Research - Volume 1103, Issue 1, 4 August 2006, Pages 25-31
نویسندگان
Andreas F. Mack, Hartwig Wolburg,