کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4332680 1292907 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Astrocyte reactivity influences the number of presynaptic terminals apposed to spinal motoneurons after axotomy
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Astrocyte reactivity influences the number of presynaptic terminals apposed to spinal motoneurons after axotomy
چکیده انگلیسی

Although synaptic plasticity is a widespread phenomenon, the underlying mechanisms leading to its occurrence are virtually unknown. In this sense, glial cells, especially astrocytes, may have a role in network changes of the nervous system, influencing the retraction of boutons as well as providing a proper perisynaptic environment, thereby affecting the replacement of inputs. Interestingly, the glial reaction does vary between strains of rats and mice. In this sense, we present evidence that C57BL/6J and A/J isogenic mice present different astrocyte reactivity after a peripheral lesion in vivo as well as in vitro, by analyzing primary cell cultures. Such a difference in the glial reaction has a direct influence on in vivo number of pre-synaptic terminals and on in vitro synaptogenesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1095, Issue 1, 20 June 2006, Pages 35–42
نویسندگان
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