کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4332709 | 1292908 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Serotonin transporter promoter variants: Analysis in Indian autistic and control population
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کلمات کلیدی
DSM-IVHaplotype-based haplotype relative riskHHRR5-hydroxytryptamine transporterSLC6A4TdT5-HTTLPRVNTR5-HTT5-hydroxytryptamineHWE5-HTtransmission disequilibrium test - آزمون عدم توازن انتقالGenetic association - ارتباط ژنتیکیAutism - اوتیسم یا درخودماندگیHardy–Weinberg equilibrium - تعادل هاردی-وینبرگVariable number of tandem repeat - تعداد متغیر تکرار tandemIndian population - جمعیت هندserotonin transporter - سروتونین حمل کنندهMeta-analysis - فرا تحلیل UTR یا untranslated regions - منطقه ترجمه نشدهuntranslated region - منطقه غیر ترجمهSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Serotonin transporter (5-HTT) is a transmembrane protein belonging to Na+/Clâ dependent membrane transporter family and transports 5-HT across the membranes of presynaptic neurons. 5-HTT-linked polymorphic region (5-HTTLPR) gained much interest because of the differential regulation of expression and activity of 5-HTT by its various genotypes. A population-based study has been conducted on 5-HTTLPR with 358 individuals, which included 79 autistic probands, 136 parents, and 143 controls from two subpopulations of east and northeast regions of India. The genotypic frequencies of all the groups conform to Hardy-Weinberg equilibrium. With the finding of efficacy of serotonin reuptake inhibitors in ameliorating ritualistic behavior in autistic disorder, 5-HTT emerged as a putative candidate gene for autism and association studies have been carried out in different ethnic populations. But these studies were inconclusive due to conflicting results on association. Because such a study has never been performed in the Indian population, we have tested the possible involvement of 5-HTTLPR polymorphism with autism. The present study failed to establish any association or linkage of 5-HTTLPR with autism in the Indian population by case-control studies (Ï2Â =Â 1.314, PÂ =Â 0.63) and family-based approaches (TDT Ï2Â =Â 0.22, PÂ =Â 0.64 and HHRR-Ï2Â =Â 0.25, PÂ =Â 0.61). However, when a meta-analysis of all the available TDT data, inclusive of the present study is carried out, we observed a significant preferential transmission of S-allele from parents to the affected offspring (Ï2Â =Â 7.51, PÂ =Â 0.006) indicating an association of 5-HTTLPR with autism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1092, Issue 1, 30 May 2006, Pages 28-35
Journal: Brain Research - Volume 1092, Issue 1, 30 May 2006, Pages 28-35
نویسندگان
Subhrangshu Guhathakurta, Sagarmoy Ghosh, Swagata Sinha, Anindita Chatterjee, Shabina Ahmed, Susanta Roy Chowdhury, Prasanta Kumar Gangopadhyay, Saurabh Ghosh, Manoranjan Singh, Rajamma Usha,