کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4332782 | 1292910 | 2006 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Influence of ionizing radiation on the course of kindled epileptogenesis
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کلمات کلیدی
ADTGFAPGSTNeuNPMA - LDC هاgeneralized seizure threshold - آستانه تشنج عمومیImmunohistochemistry - ایمونوهیستوشیمیgeneralized estimating equations - برآورد معادلات تعمیم یافتهafterdischarge threshold - بعد از تخلیه آستانهionizing radiation - تابش یوننده یا پرتوهای یونیزانGEE - جیdentate gyrus - شکنج دندانه دارGrowth factor - فاکتور رشدGlial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایالkindling - چطوری
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Several clinical and experimental reports suggest that low-dose irradiation of an established epileptic focus can reduce the occurrence of spontaneous seizures. Conversely, some recent reports suggest that under some conditions low-dose irradiation may have disinhibitory effects on seizure expression. Here, we have investigated mechanistic aspects of this phenomenon in the kindling model of epilepsy by applying focal irradiation at various points during kindling development. Rats were kindled to stage 5 by afterdischarge-threshold electrostimulation of the left amygdala. Treatment groups were irradiated using a collimated X-ray beam (18Â MV) either prior to kindling, at kindling stage 3, or at kindling stage 5, by exposure of the left amygdala to a single-fraction central-axis dose of 25Â Gy. Generalized seizure thresholds (GSTs) were subsequently assayed at weekly intervals for 10Â weeks and at monthly intervals for an additional 3Â months, along with the severity of the evoked seizures. Irradiation produced no significant effects on seizure threshold, but did produce persistent changes in seizure severity which varied as a function of the timing of irradiation. Relative to sham irradiated controls, the occurrence of stage 6 seizures was significantly increased by irradiation prior to kindling, but was unaffected by irradiation at kindling stage 3, and significantly reduced by irradiation at kindling stage 5. Quantitative immunohistochemical assays for neuron and astrocyte densities within the amygdala and hippocampus revealed only subtle changes in neuronal density within the dentate granule cell layer. These results are discussed in relation to mechanisms of seizure- and radiation-induced plasticity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1094, Issue 1, 13 June 2006, Pages 207-216
Journal: Brain Research - Volume 1094, Issue 1, 13 June 2006, Pages 207-216
نویسندگان
Kenneth A. Jenrow, Alexander E. Ratkewicz, Danielle N. Zalinski, Kathleen M. Roszka, Nancy W. Lemke, Kost V. Elisevich,