کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4332818 1292912 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mouse models as a tool to unravel the genetic basis for human otitis media
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Mouse models as a tool to unravel the genetic basis for human otitis media
چکیده انگلیسی

The pathogenesis of otitis media (OM) is multifactorial and includes infection, anatomical factors, immunologic status, genetic predisposition, and environmental factors. OM remains the most common cause of hearing impairment in childhood. Genetic predisposition is increasingly recognized as an important factor. The completion of the mouse genome sequence has offered a powerful basket of tools for investigating gene function and can expect to generate a rich resource of mouse mutants for the elucidation of genetic factors underlying OM. We review the literature and discuss recent progresses in developing mouse models and using mouse models to uncover the genetic basis for human OM.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1091, Issue 1, 26 May 2006, Pages 9–15
نویسندگان
, , ,