کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4332846 | 1292912 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The adult mouse utricle as an in vitro preparation for studies of ototoxic-drug-induced sensory hair cell death
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The adult mouse utricle as an in vitro preparation for studies of ototoxic-drug-induced sensory hair cell death The adult mouse utricle as an in vitro preparation for studies of ototoxic-drug-induced sensory hair cell death](/preview/png/4332846.png)
چکیده انگلیسی
Sensory hair cells of the inner ear are susceptible to death from a variety of stresses including aging, noise trauma, genetic disorders, and exposure to certain therapeutic drugs. Ototoxic drugs include the aminoglycoside antibiotics and the antineoplastic agent cisplatin. This is a short technical report describing the dissection and culture of the adult mouse utricle. This in vitro preparation allows for detailed studies of ototoxic-drug-induced hair cell death in an adult mammalian system. In addition, this preparation allows for examination of the effects of specific gene products through the use of transgenic and knockout mouse models.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1091, Issue 1, 26 May 2006, Pages 277–281
Journal: Brain Research - Volume 1091, Issue 1, 26 May 2006, Pages 277–281
نویسندگان
Lisa L. Cunningham,