کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4333244 | 1292926 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Therapeutic action of cannabinoid on axonal injury induced by peroxynitrite
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Therapeutic action of cannabinoid on axonal injury induced by peroxynitrite Therapeutic action of cannabinoid on axonal injury induced by peroxynitrite](/preview/png/4333244.png)
چکیده انگلیسی
This study examined whether the potent cannabinoid HU210 ameliorates axonal injury through its indirect action to stimulate the secretion of corticosterone. We observed that HU210 dramatically reduced peroxynitrite-induced axonal injury in rats receiving adrenalectomy and corticosterone replacement treatment. These results suggest that the ameliorating effects of cannabinoids on axonal injury associated with multiple sclerosis are achieved by its direct action, but not by its indirect action to elevate the serum corticosterone levels.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1076, Issue 1, 3 March 2006, Pages 238–242
Journal: Brain Research - Volume 1076, Issue 1, 3 March 2006, Pages 238–242
نویسندگان
C. Yang, W. Hader, X. Zhang,