کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4333332 | 1614318 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Enhanced expression of heat shock protein 27 is correlated with axonal regeneration in mature retinal ganglion cells
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کلمات کلیدی
RGCFluorogoldAxonogenesisHSP27PNGalpha-crystallin - آلفا کریستالینCNS - دستگاه عصبی مرکزیretinal ganglion cell - سلول گانگلیونی شبکیهcentral nervous system - سیستم عصبی مرکزیTrophic factor - فاکتور جادوییStress response - پاسخ به استرسHeat shock protein 27 - پروتئین شوک حرارت 27Peripheral nerve graft - پیوند عصبی محیطی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The small heat shock protein, Hsp27, promotes axonal regeneration in peripheral neurons; however, an analogous role in the central nervous system has not been described. This study examined the relationship between Hsp27 expression and regeneration in mature retinal ganglion cells (RGCs). Adult rat optic nerves were transected and exposed to peripheral nerve autografts to stimulate regeneration of cut RGC axons. There was a five-fold increase in the Hsp27-positive fraction of RGCs that extended new axons into the graft when compared with those that survived injury but did not regenerate (30% versus 6% respectively, PÂ =Â 0.001). Hsp27 protein was located throughout somata and neuritic processes, and there was a significant positive correlation between Hsp27 expression and axonal regeneration in injured neurons (RÂ =Â 0.92, PÂ <Â 0.0001). These findings are consistent with the growth-associated role of Hsp27 demonstrated in peripheral neurons and suggest that Hsp27 may mediate similar physiological functions in the central nervous system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volumes 1073â1074, 16 February 2006, Pages 146-150
Journal: Brain Research - Volumes 1073â1074, 16 February 2006, Pages 146-150
نویسندگان
Matthew O. Hebb, Tanya L. Myers, David B. Clarke,