Induction of CITED2 expression in the rat hippocampus following transient global ischemia

CITED2 is implicated in the modulating the activity of HIF-1 which is a major transcription factor involved in ischemia-related gene expression. Following transient forebrain ischemia, we found that CITED2 was induced in a subset of brain regions including dentate gyrus of the hippocampal formation and piriform cortex. Because CITED2 was not induced in cultured neurons exposed to oxygen–glucose deprivation, we concluded that hypoxia is not sufficient to trigger its induction.