کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4335742 | 1295178 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Automated measurement of Drosophila jump reflex habituation and its use for mutant screening
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Automated measurement of Drosophila jump reflex habituation and its use for mutant screening Automated measurement of Drosophila jump reflex habituation and its use for mutant screening](/preview/png/4335742.png)
چکیده انگلیسی
In habituation the probability of a behavioral response decreases with repeated presentations of a stimulus. This is a simple kind of learning since it involves an adaptive change in behavior due to experience. The present study describes a high-throughput semi-automated system to track movement of individual flies and score their jump response to repeated presentations of an odor. We find a decreased response on repeated presentations of odor, which a number of criteria suggest to be habituation. Tracking of up to sixteen flies simultaneously allows analysis of large numbers of flies for mutant screens. We demonstrate the use of the Autojump system for large-scale screens by conducting a pilot-scale screen of 150 P insert lines for habituation mutants.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroscience Methods - Volume 182, Issue 1, 30 August 2009, Pages 43-48
Journal: Journal of Neuroscience Methods - Volume 182, Issue 1, 30 August 2009, Pages 43-48
نویسندگان
Punita Sharma, John Keane, Cahir J. O'Kane, Zoltan Asztalos,