کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4336593 1295219 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A chronically implantable, hybrid cannula–electrode device for assessing the effects of molecules on electrophysiological signals in freely behaving animals
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
A chronically implantable, hybrid cannula–electrode device for assessing the effects of molecules on electrophysiological signals in freely behaving animals
چکیده انگلیسی

We describe a device for assessing the effects of diffusible molecules on electrophysiological recordings from multiple neurons. This device allows for the infusion of reagents through a cannula located among an array of micro-electrodes. The device can easily be customized to target specific neural structures. It is designed to be chronically implanted so that isolated neural units and local field potentials are recorded over the course of several weeks or months. Multivariate statistical and spectral analysis of electrophysiological signals acquired using this system could quantitatively identify electrical “signatures” of therapeutically useful drugs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroscience Methods - Volume 163, Issue 2, 30 July 2007, Pages 321–325
نویسندگان
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