کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4336680 | 1295223 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Magnetic resonance angiography of carotid and cerebral arterial occlusion in rats using a clinical scanner
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کلمات کلیدی
Magnetic resonance angiography - آنژیوگرافی رزونانس مغناطیسیmiddle cerebral artery occlusion - انسداد شریان (سرخرگ) مغزی میانیCerebral ischemia - ایسکمی مغزیbilateral common carotid artery occlusion - دو طرفه انسداد شریان کاروتید مشترکModel - مدلRat - موش صحراییChronic cerebral hypoperfusion - هیپرفرفی عروق کرونر
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Magnetic resonance angiography of carotid and cerebral arterial occlusion in rats using a clinical scanner Magnetic resonance angiography of carotid and cerebral arterial occlusion in rats using a clinical scanner](/preview/png/4336680.png)
چکیده انگلیسی
In rat models to induce both focal cerebral ischemia and chronic cerebral hypoperfusion, it is highly desirable to verify the success of vessel occlusion and reopening with non-invasive method. The contrast-agent free 3D time-of-flight magnetic resonance angiography (TOF-MRA), diffusion-weighted imaging (DWI) and T2-weighted imaging by 3.0-T MR clinical scanner were applied when unilateral middle cerebral artery (MCA) was occluded and reopened, and after bilateral common carotid arteries were in ligation. The arterial angiograms of the rat brain and neck were achieved successfully in all chosen directions by the 3D TOF-MRA. It was shown that MCA in occlusion presented no signal in MRA, and the parenchyma of the ipsilateral MCA territory hypointensity signal in maps of apparent diffusion coefficient (ADC). After reperfusion, the signal intensity of ipsilateral MCA was resumed in MRA, and the decreased ADC was restored simultaneously. However, after 5Â h of reperfusion, it was found that the value of ADC deteriorated second time with high T2 value. In bilateral common carotid artery occlusion (BCCAO) rats, it can be confirmed by MRA that the effectively occluded BCCA presented the absent signal and the basilar artery became tortuous. As a result, MRA by clinical scanner was proved of a valuable method to validate transient middle cerebral artery occlusion (MCAO) and permanent BCCAO rat model.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroscience Methods - Volume 167, Issue 2, 30 January 2008, Pages 176-183
Journal: Journal of Neuroscience Methods - Volume 167, Issue 2, 30 January 2008, Pages 176-183
نویسندگان
Yan Mei Yang, XiaoYuan Feng, Zhen Wei Yao, Wei Jun Tang, Han Qiu Liu, Li Zhang,