کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4336995 1295236 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Irregularity in neocortical spike trains: Influence of measurement factors and another method of estimation
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Irregularity in neocortical spike trains: Influence of measurement factors and another method of estimation
چکیده انگلیسی
Irregularity in the interspike interval is a common phenomenon especially in the neocortex. A measure of this random variation in the spacing between neuronal spikes is usually obtained with the coefficient of variation CV (standard deviation/mean interspike interval). In excitable cells, the standard deviation in the interspike interval can be large and the mean firing rate often fluctuates. As a result, there can be substantial variability in the value of the CV computed for the same spike train using only slightly different samples as we show. Moreover, these CV values can be comparatively meaningless unless certain conditions are met. In doing so some researchers have selectively sampled data over a stable mean while others have used a wide range of trial times or subsets thereof (capture window) to compute the CV. This has made interpretation of the raw CV cumbersome. We demonstrate that the CV has a triple sensitivity, namely, for the size of the capture window, the spike count and the refractory period. We assuage these difficulties by introducing a modified term, the coefficient of variation proportion of maximum (CVpm) that offers transportability across different experimental conditions by compensating for the triplet.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroscience Methods - Volume 157, Issue 2, 30 October 2006, Pages 264-273
نویسندگان
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