کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4337469 1614777 2015 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Drift in centrality of different brain regions in an anatomical neural network with Parkinson’s disease: A view from complex network analysis
ترجمه فارسی عنوان
رانش در مرکزیت مناطق مغزی مختلف در شبکه عصبی آناتومیک با بیماری پارکینسون: یک دیدگاه از تجزیه و تحلیل شبکه پیچیده
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


• Development of weight allocation algorithms to merge different anatomical studies.
• Building a whole brain network without logical overlaps in macaque.
• Simulating an advanced PD brain network by removing the substantial nigra node.
• Complex network analysis may reveal the role change of each brain region.

Understanding the role of brain regions in anatomical neural networks with Parkinson’s disease (PD) is essential for improving the clinical protocol or finding new targets for deep brain stimulation (DBS). Although numerous changes have been reported in local functional studies, few studies have reported on the anatomical network of the entire brain. Here, by developing a series of algorithms, this study provided a whole anatomical neural network of the macaque monkey. Then, the drifts in centrality from normal to PD networks were described in terms of complex network analysis and summarized with principal component analysis. Results revealed that the areas including the striatum, globus pallidus, amygdala, prefrontal lobe, thalamus, hippocampus, visual cortex, insula, etc., showed relatively notable drifts in their own patterns. The present study also demonstrated that the current targets of DBS shared a common feature: their centrality values being relatively low in the normal brain while intensely drifting with PD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 299, 23 July 2015, Pages 107–124
نویسندگان
, , , , , ,