کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4337486 | 1614783 | 2015 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Metaplastic up-regulation of LTP in the rat visual cortex by monocular visual training: Requirement of task mastery, hemispheric specificity, and NMDA-GluN2B involvement
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کلمات کلیدی
TBSinput–output curvePPRNLRLGNfield postsynaptic potentialfPSPCSDN-methyl-d-aspartateNMDAPPFaCSFAMPAS.E.M.EPSC - EPSCoRNMDA receptor - NMDA گیرندهPps - PPSVisual learning - آموزش تصویریISI - آی اس آیTheta-burst stimulation - تحریک حباب تتاcurrent source density - تراکم منبع فعلیpaired-pulse facilitation - تسکین زوایای پالسیlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP excitatory postsynaptic current - جریان پستیینپتیک تحریک کنندهstandard error of the difference - خطای استاندارد از تفاوتstandard error of the mean - خطای استاندارد میانگینPaired-pulse stimulation - زوج تحریک پالسPaired-pulse - زوج پالسinter-stimulus interval - فاصله بین محرکprimary visual cortex - قشر بصری اولیهVisual cortex - قشر ویژوالartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیmetaplasticity - متاپلستیکpaired-pulse ratio - نسبت پالس زوجlateral geniculate nucleus - هسته ژنیکول جانبی جانبی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
“Metaplasticity” is defined as an alteration of synaptic plasticity properties or mechanisms by a priming event without actual changes in synaptic strength. For example, visual discrimination training of rats leads to a facilitation of the subsequent induction of long-term potentiation (LTP) between the lateral geniculate nucleus (LGN) and the primary visual cortex (V1). Here, rats received visual discrimination training in a modified water maze, with one eye occluded during training to create monocular viewing conditions; 63% of rats acquired the task under these conditions. Following training, in vivo electrophysiology was used to examine LTP of field postsynaptic potentials (fPSPs) in V1 elicited by LGN stimulation. Rats that had successfully learned the task showed significantly greater LTP in the “trained V1” (contralateral to the open, trained eye) relative to the “untrained” hemisphere. Rats that underwent training but failed to acquire the task did not show this lateralized plasticity enhancement and had similar levels of LTP in both cerebral hemispheres. Cortical application of the NMDA receptor-GluN2B subunit antagonist Ro 25-6981 (2Â mM) reversed the training-induced LTP facilitation without affecting LTP in the untrained V1. Whole-cell patch clamp recordings of V1 (layers II/III) pyramidal cells in vitro demonstrated that pharmacologically isolated NMDA currents exhibit a greater sensitivity to GluN2B blockade in the trained relative to the untrained V1. Together, these experiments reveal a surprising degree of anatomical (only in the hemisphere contralateral to the trained eye) and behavioral specificity (only in rats that mastered the task) for the effect of visual training to enhance LTP in V1. Further, cortical GluN2B subunits appear to be directly involved in this metaplastic facilitation of thalamocortical plasticity, suggesting that NMDA subunit composition or functioning is, at least in part, regulated by the exposure to behaviorally significant stimuli in an animal's sensory environment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 293, 7 May 2015, Pages 171-186
Journal: Neuroscience - Volume 293, 7 May 2015, Pages 171-186
نویسندگان
A.M. Hager, P.J. Gagolewicz, S. Rodier, M.-C. Kuo, Ã.C. Dumont, H.C. Dringenberg,