کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4337667 1614812 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanisms of transgenerational inheritance of addictive-like behaviors
ترجمه فارسی عنوان
مکانیسم ارثی نسبی رفتارهای اعتیاد آور
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


• Environmental exposure to drugs alters the epigenome and is transmitted to future generations.
• Epigenome provides a direct mechanism for drugs to alter the genetic events involved in addiction.
• Epigenetics presents a mechanism of heritability of addictive phenotypes.

Genetic factors are implicated in the heritability of drug abuse. However, even with advances in current technology no specific genes have been identified that are critical for the transmission of drug-induced phenotypes to subsequent generations. It is now evident that epigenetic factors contribute to disease heritability and represent a link between genes and the environment. Recently, epigenetic mechanisms have been shown to underlie drug-induced structural, synaptic, and behavioral plasticity by coordinating the expression of gene networks within the brain. Therefore, the epigenome provides a direct mechanism for drugs of abuse to influence the genetic events involved in the development of addiction as well as its heritability to subsequent generations. In this review we discuss the mechanisms underlying intergenerational epigenetic transmission, highlight studies that demonstrate this phenomenon with particular attention to the field of addiction, and identify gaps for future studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 264, 4 April 2014, Pages 198–206
نویسندگان
, ,