کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4337758 1614818 2014 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chordin expression in the adult rat brain
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Chordin expression in the adult rat brain
چکیده انگلیسی


• We investigated chordin expression in the adult rat CNS using immunohistochemistry.
• Chordin is expressed throughout the adult CNS.
• We observed that chordin is abundantly expressed in many kinds of axons.
• We found strong chordin expression in the apical dendrites of pyramidal cells.
• We also exhibited chordin expression in astrocytes and ependymal cells.

Bone morphogenetic proteins (BMPs) exert its biological functions by interacting with membrane bound receptors. However, functions of BMPs are also regulated in the extracellular space by secreted antagonistic regulators. Chordin is an extracellular BMP antagonist that binds BMP-2, 4, and 7 with high affinity and thus interferes with binding to BMP receptors. Although chordin expression has been well described in the early development of the CNS, little information is available for its expression in the adult CNS. We, thus, investigated chordin expression in the adult rat CNS using immunohistochemistry. Chordin was intensely expressed in most neurons, and their dendrites and axons. In addition, abundant chordin expression was also observed in the neuropil of the gray matters where high plasticity is reported, such as the molecular layer of the cerebellum and the superficial layer of the superior colliculus. Furthermore, we found that astrocytes and ependymal cells also express chordin protein. These data indicate that chordin is more widely expressed throughout the adult CNS than previously reported, and its continued abundant expression in the adult brain strongly supports the idea that chordin plays pivotal roles also in the adult brain.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 258, 31 January 2014, Pages 16–33
نویسندگان
, ,