Keywords: محدود، افسردگی طولانی مدت; DBS, deep brain stimulation; HFS, high-frequency stimulation; LTD, long-term depression; PCLS, post-closed-loop stimulation; PIR, Passive-Infrared-Registration; PYS, post-yoked-stimulation; SN, subthalamic nucleus; SWD, spike-wave dischargesspike-wave dis
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Keywords: محدود، افسردگی طولانی مدت; aCSF, artificial cerebrospinal fluid; CED, Cambridge Electronic Design; CNS, central nervous system; DCC, Deleted in Colorectal Cancer; fEPSPs, field excitatory postsynaptic potentials; HRP, horse radish peroxidase; LTD, long-term depression; LTP, long-te
Keywords: محدود، افسردگی طولانی مدت; ACh, Acetylcholine; E/I, excitatory-to-inhibitory; LTD, long-term depression; LTP, long-term potentiation; nAChR, nicotinic acetylcholine receptor; α7KO, α7-nAChR constitutive knockout mouse; O–LM, oriens–lacunosum moleculare; PV, parvalbumin; 5-HT3AR, se
Keywords: محدود، افسردگی طولانی مدت; WHP, Warsaw High Preferring rat strain; WLP, Warsaw Low Preferring rat strain; mPFC, prefrontal medial cortex; HP, hippocampus; NAc, nucleus accumbens; GEO, Gene Expression Omnibus database; LTP, long-term potentiation; LTD, long-term depression; AA, ALCO
Keywords: محدود، افسردگی طولانی مدت; ACSF, artificial cerebrospinal fluid; FP, field potential; IMI, imipramine; LA, lateral amygdala; LFS, low frequency stimulation; LTD, long-term depression; LTP, long-term potentiation; MS, maternal separation; PND, postnatal day; TBS, theta burst stimula
Memantine alters striatal plasticity inducing a shift of synaptic responses toward long-term depression
Keywords: محدود، افسردگی طولانی مدت; Memantine; Striatum; Synaptic plasticity; LTP; LTD; NMDA receptor; D2 receptorSPNs, spiny projection neurons; LTP, long-term potentiation; LTD, long-term depression; NMDA, N-Methyl-d-Aspartate; HFS, high frequency stimulation; DA, dopamine; AD, Alzheimer'
d-Serine rescues the deficits of hippocampal long-term potentiation and learning and memory induced by sodium fluoroacetate
Keywords: محدود، افسردگی طولانی مدت; FAC, sodium fluoroacetate; LTP, long-term potentiation; LTD, long-term depression; NMDAR, N-methyl d-aspartate receptor; DAAO, d-amino acid oxidase; fEPSP, field excitatory postsynaptic potential; TBS, theta-burst stimulation; CNS, central nervous systemd
The effect of α7 nicotinic receptor activation on glutamatergic transmission in the hippocampus
Keywords: محدود، افسردگی طولانی مدت; ACh, acetylcholine; DG, dentate gyrus; HFS, high frequency stimulation; LTD, long-term depression; LTP, long-term potentiation; nAChR, nicotinic ACh receptor; STP, short-term potentiation; PAM, positive allosteric modulatorα7 Nicotinic acetylcholine recep
Danggui-Jakyak-San enhances hippocampal long-term potentiation through the ERK/CREB/BDNF cascade
Keywords: محدود، افسردگی طولانی مدت; DJS, Danggui-Jakyak-San; ERK1/2, extracellular signal-regulated kinase 1/2; CREB, cAMP response element-binding protein; BDNF, brain-derived neurotropic factor; LTP, long-term potentiation; LTD, long-term depression; fEPSP, field excitatory postsynaptic p
Chronic sodium salicylate administration enhances population spike long-term potentiation following a combination of theta frequency primed-burst stimulation and the transient application of pentylenetetrazol in rat CA1 hippocampal neurons
Keywords: محدود، افسردگی طولانی مدت; aCSF, artificial cerebrospinal fluid; CA1, cornus ammonis 1; fEPSP, field excitatory postsynaptic potential; GABA, gamma-amino butyric acid; LTD, long-term depression; LTP, long-term potentiation; NMDA, N-methyl-d-aspartate; PTZ, pentyleneterazol; PBs, pr
Nampt is required for long-term depression and the function of GluN2B subunit-containing NMDA receptors
Keywords: محدود، افسردگی طولانی مدت; CA1, cornu ammonis region 1; fEPSP, field excitatory postsynaptic potential; HFS, high frequency stimulation; LTD, long-term depression; LTP, long-term potentiation; LFS, low frequency stimulation; NAD+, nicotinamide adenine dinucleotide; Nampt, nicotinam
Inactivation of adenosine A2A receptors reverses working memory deficits at early stages of Huntington's disease models
Keywords: محدود، افسردگی طولانی مدت; A2AR, adenosine A2A receptor; aCSF, artificial cerebrospinal fluid; DARPP-32, dopamine- and cAMP-regulated phosphoprotein with molecular weight of 32 kDa; HD, Huntington's disease; KO, knock out; LTD, long-term depression; LTP, long-term potentiation; PN,
Intranigral lipopolysaccharide induced anxiety and depression by altered BDNF mRNA expression in rat hippocampus
Keywords: محدود، افسردگی طولانی مدت; Anxiety; BDNF mRNA expression; Depression; Lipopolysaccharide; Parkinson's diseaseBDNF, brain-derived neurotrophic factor; LPS, lipopolysaccharide; PD, Parkinson's disease; LTP, long-term potentiation; LTD, long-term depression; IL-1ß, interleukin-1ß; SN,
Peripheral and intra-dorsolateral striatum injections of the cannabinoid receptor agonist WIN 55,212-2 impair consolidation of stimulus–response memory
Keywords: محدود، افسردگی طولانی مدت; Δ9THC, Δ9-tetrahydrocannabinol; ANOVA, analysis of variance; BLA, basolateral complex of the amygdala; CB1Rs, cannabinoid 1 receptors; DLS, dorsolateral striatum; DMSO, dimethyl sulfoxide; ITI, intertrial interval; LTD, long-term depression; PEG, polyethy
Chordin expression in the adult rat brain
Keywords: محدود، افسردگی طولانی مدت; BMP, bone morphogenetic protein; BMPR, bone morphogenetic protein receptor; BSA, bovine serum albumin; DCX, doublecortin; GFAP, glial fibrillary acidic protein; IR, like immunoreactivity; LTD, long-term depression; LTP, long-term potentiation; MAP2, micro
NMDA GluN2B receptors involved in the antidepressant effects of curcumin in the forced swim test
Keywords: محدود، افسردگی طولانی مدت; NMDA, N-methyl-D-aspartate; (DCS), D-cycloserine; LTP, Long-term potentiation; LTD, long-term depression; ANOVA, analysis of varianceAntidepressant; Curcumin; Forced swim test; GluN2B; NMDA receptor
The trouble with spines in fragile X syndrome: density, maturity and plasticity
Keywords: محدود، افسردگی طولانی مدت; Div, days in vitro; EM, electron microscopy; FMRP, fragile X mental retardation protein; FXS, fragile X syndrome; GFP, green fluorescent protein; KO, knockout; L, layer; LTD, long-term depression; LTP, long-term potentiation; mGluR, metabotropic glutamate
Dysregulation of synaptic proteins, dendritic spine abnormalities and pathological plasticity of synapses as experience-dependent mediators of cognitive and psychiatric symptoms in Huntington’s disease
Keywords: محدود، افسردگی طولانی مدت; BDNF, brain-derived neurotrophic factor; CAG, cytosine-adenine-guanine trinucleotide; EE, environmental enrichment; F-actin, actin filaments; HD, Huntington’s disease; htt, huntingtin; LTD, long-term depression; LTP, long-term potentiation; PSD, postsynap
Impaired maturation of serotonergic function in the dentate gyrus associated with epilepsy
Keywords: محدود، افسردگی طولانی مدت; ACSF, artificial cerebrospinal fluid; EPSC, excitatory postsynaptic current; HCN, Hyperpolarization-activated Cyclic Nucleotide-gated channel; IPSC, inhibitory postsynaptic current; LTD, long-term depression; PKC, protein kinase C; PPR, paired pulse ratio
Dendritic spine pathology in epilepsy: Cause or consequence?
Keywords: محدود، افسردگی طولانی مدت; LTD, long-term depression; LTP, long-term potentiation; MECP2, methyl-CpG-binding protein-2; mTOR, mammalian target of rapamycin; NMDA, N-methyl-d-aspartate; TSC, tuberous sclerosis complexseizure; epilepsy; epileptogenesis; dendrite; actin
Brain transcriptome perturbations in the transferrin receptor 2 mutant mouse support the case for brain changes in iron loading disorders, including effects relating to long-term depression and long-term potentiation
Keywords: محدود، افسردگی طولانی مدت; cDNA, complementary DNA; ICP-AES, inductively coupled plasma atomic emission spectroscopy; IgG–HRP, immunoglobulin G–horseradish peroxidase; IRE/IRP, iron-responsive element/iron regulatory protein; LTD, long-term depression; LTP, long-term potentiation;
MHC class I protein is expressed by neurons and neural progenitors in mid-gestation mouse brain
Keywords: محدود، افسردگی طولانی مدت; β2m, beta-2 microglobulin; CNS, central nervous system; HES cell, human embryonic stem cell; LGN, lateral geniculate nucleus; LTD, long-term depression; LTP, long-term potentiation; MHCI, major histocompatibility complex class I; NSC, neural stem cell; PN
Biophysical mechanisms regulating AMPA receptor accumulation at synapses
Keywords: محدود، افسردگی طولانی مدت; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate; PSD, post-synaptic density; EZ, endocytic zone; LTP, long-term potentiation; LTD, long-term depression; MSD, mean squared displacement; SPT, single particle tracking; FRAP, fluorescence recovery afte
The effects of abused drugs on adolescent development of corticolimbic circuitry and behavior
Keywords: محدود، افسردگی طولانی مدت; BLA, basolateral amygdala; CRH, corticotropin-releasing hormone; EEG, electroencephalography; LTD, long-term depression; LTP, long-term potentiation; mPFC, medial prefrontal cortex; MRI, magnetic resonance imaging; NAc, nucleus accumbens; NMDA, N-methyl-d
Brain-derived neurotrophic factor–estrogen interactions in the hippocampal mossy fiber pathway: Implications for normal brain function and disease
Keywords: محدود، افسردگی طولانی مدت; BDNF, brain-derived neurotrophic factor; CaMK, Ca2+/calmodulin-dependent protein kinase; CREB, cyclic AMP response element-binding protein; DG, dentate gyrus; Egr3, early growth response factor-3; ER, estrogen receptor; LTD, long-term depression; LTP, lon
Calcineurin is required for TRPV1-induced long-term depression of hippocampal interneurons
Keywords: محدود، افسردگی طولانی مدت; TRPV1, transient receptor potential vanilloid 1; LTD, long-term depression; CA3, Cornu Ammonis 3; HFS, high frequency stimulus; EPSC, excitatory postsynaptic potentialPPP3; LTD; PP2B; Hippocampus; Synaptic plasticity
Glutamate receptor subunit GluA1 is necessary for long-term potentiation and synapse unsilencing, but not long-term depression in mouse hippocampus
Keywords: محدود، افسردگی طولانی مدت; AMPA, AMPAR, Alpha-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid (receptor); NMDA, NMDAR, N-methyl-d-aspartate (receptor); LTP, long-term potentiation; LTD, long-term depression; GluA1 (GluA2,3), AMPA receptor subunit type 1 (type 2,3); LFS, low-fre
Comparison of long-term potentiation (LTP) in the medial (monocular) and lateral (binocular) rat primary visual cortex
Keywords: محدود، افسردگی طولانی مدت; ANOVA, analysis of variance; dLGN, dorsal lateral geniculate nucleus; fPSP, field postsynaptic potential; i.p., intraperitoneal; LTD, long-term depression; LTP, long-term potentiation; NMDA, N-methyl-D-aspartate; V1, primary visual cortex; m-V1, medial pr
Influence of sex and estrous cycle on synaptic responses of the medial vestibular nuclei in rats: Role of circulating 17β-estradiol
Keywords: محدود، افسردگی طولانی مدت; ACSF, artificial cerebrospinal fluid; DE, diestrus; DHT, 5α-dihydrotestosterone; E2, 17β-estradiol; HFS, high frequency stimulation; LTD, long-term depression; LTP, long-term potentiation; MVN, medial vestibular nucleus; NMDAR, N-methyl-d-aspartate recept
Aberrant striatal synaptic plasticity in monogenic parkinsonisms
Keywords: محدود، افسردگی طولانی مدت; Parkinson's disease; synaptic plasticity; striatum; animal modelDA, dopamine; DAT, DA transporter; LRRK2, leucine-rich repeat kinase 2; LTD, long-term depression; LTP, long-term potentiation; PD, Parkinson's disease; PET, positron emission tomography; SNC
Post-weaning mice fed exclusively milk have deficits in induction of long-term depression in the CA1 hippocampal region and spatial learning and memory
Keywords: محدود، افسردگی طولانی مدت; Me5, mesencephalic trigeminal nucleus; DG, dentate gyrus; NeuN, neuronal nuclei; BrdU, 5-bromo-2′-deoxyuridine; LTP, long-term potentiation; LTD, long-term depression; TBS, theta burst stimulation; LFS, low frequency stimulationWeaning; Dentate gyrus; CA1
Climbing fiber activity reduces 14-3-3-θ regulated GABAA receptor phosphorylation in cerebellar Purkinje cells
Keywords: محدود، افسردگی طولانی مدت; climbing fiber; flocculus; GABAAγ2; 14-3-3-θ; protein kinase C; serine phosphorylationCRF, corticotropin-releasing factor; GABARAP, GABAAR-associated protein; HOKS, horizontal optokinetic stimulation; LTD, long-term depression; LTP, long-term potentiation
Intravitreous interleukin-2 treatment and inflammation modulates glial cells activation and uncrossed retinotectal development
Keywords: محدود، افسردگی طولانی مدت; IL-2; critical period; development; superior colliculus; plasticity; glial cellsDAPI, 4′,6-diamidino-2-phenylindole; GFAP, glial fibrillary acidic protein; HRP, horseradish peroxidase; IL-2, interleukin-2; LTD, long-term depression; LTP, long-term potenti
Morphine-induced modulation of LTD at GABAergic synapses in the ventral tegmental area
Keywords: محدود، افسردگی طولانی مدت; LTP; LTD; Morphine; VTA; Addiction; Synaptic plasticityLTP, Long-term potentiation; LTD, long-term depression; VTA, ventral tegmental area; NAc, nucleus accumbens; DA, dopamine; NO, nitric oxide; NMDAR, NMDA receptor; CB1R, cannabinoid CB1 receptor; eCB,
Novel insights into CaMKII function and regulation during memory formation
Keywords: محدود، افسردگی طولانی مدت; CaMKII, Ca2+/calmodulin-dependent kinase II; CaMKIIN, endogenous CaMKII inhibitor protein; E-LTP, early LTP; L-LTP, late LTP; LTD, long-term depression; LTP, long-term potentiation; NMDA, N-methyl-d-aspartate; PSD, post-synaptic density; STP, short-term p
Opiates and plasticity
Keywords: محدود، افسردگی طولانی مدت; Synaptic plasticity; LTP; LTD; Opiates; Addiction; DopamineLTP, Long-term potentiation; LTD, long-term depression; VTA, ventral tegmental area; NAc, nucleus accumbens; PFC, prefrontal cortex; mPFC, medial PFC; DA, dopamine; eCB, endocannabinoids; PKA, pro
Modulatory effects of serotonin on glutamatergic synaptic transmission and long-term depression in the deep cerebellar nuclei
Keywords: محدود، افسردگی طولانی مدت; deep cerebellar nuclei; mossy fibre; serotonin; long-term depression; modulationACSF, artificial cerebrospinal fluid; DCN, deep cerebellar nuclei; DHPG, (S)-3,5-dihydroxyphenylglycine; EPSC, excitatory postsynaptic current; LTD, long-term depression; LTP,
Emotional tagging—A simple hypothesis in a complex reality
Keywords: محدود، افسردگی طولانی مدت; LTD, long-term depression; LTP, long-term potentiation; E-LTP, early-LTP; L-LTP, late-LTP; DG, dentate gyrus; PRPs, plasticity-related proteins; MAPK, mitogen-activated kinase; MFB, medial forebrain bundle; LA, lateral amygdala; B, basal amygdala; BLA, th
Dopaminergic modulation of striatal neurons, circuits, and assemblies
Keywords: محدود، افسردگی طولانی مدت; striatum; dopamine; synaptic platicity; canonical circuits; cell assembliesCA, cell assemblies; DA, dopamine; dSPN, direct pathway SPN; ENK, enkephalin; FS, fast-spiking; iSPN, indirect pathway SPN; LTD, long-term depression; LTP, long-term potentiation;
Control of synapse development and plasticity by Rho GTPase regulatory proteins
Keywords: محدود، افسردگی طولانی مدت; GEF, guanine nucleotide exchange factor; GAP, GTPase-activating protein; LTP, long-term potentiation; LTD, long-term depression; F-actin, filamentous actin; CNS, central nervous system; PH, pleckstrin homology domain; CC-Ex, coiled coil-extended region; R
Dynamic, experience-dependent modulation of synaptic zinc within the excitatory synapses of the mouse barrel cortex
Keywords: محدود، افسردگی طولانی مدت; barrel cortex; cortical plasticity; ultrastructure; whisker; zincE.M.S., Electron Microscopy Sciences; LTD, long-term depression; LTP, long-term potentiation; NMDA, N-methyl-d-aspartic acid
Theta oscillations during holeboard training in rats: different learning strategies entail different context-dependent modulations in the hippocampus
Keywords: محدود، افسردگی طولانی مدت; learning; dentate gyrus; field potentials; cognitive reinforcement; theta oscillations; information processingAP, anterior-posterior; CA1, cornu-ammonis area 1; DV, dorso-ventral; LFP, local field potential; LTD, long-term depression; LTP, long-term poten
Differential regulation of synapsin phosphorylation by monocular deprivation in juveniles and adults
Keywords: محدود، افسردگی طولانی مدت; ocular dominance; development; synapsinAMPA, α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate; cAMP, cyclic AMP; HFS, high frequency stimulation; LFS, low frequency stimulation; LTD, long-term depression; LTP, long-term potentiation; NMDA, N-methyl-d-as
Changes in ensemble activity of hippocampus CA1 neurons induced by chronic morphine administration in freely behaving mice
Keywords: محدود، افسردگی طولانی مدت; hippocampus; ensemble activity; chronic morphine administration; multi-channel recordings; freely behaving miceAE, active exploration; CPP, conditioned place preference; DA, dopamine; LFP, local field potential; LTD, long-term depression; LTP, long-term p
Disrupted topography of the acquired trace-conditioned eyeblink responses in guinea pigs after suppression of cerebellar cortical inhibition to the interpositus nucleus
Keywords: محدود، افسردگی طولانی مدت; aCSF, artificial cerebrospinal fluid; BICM, bicuculline methiodide; CR, conditioned eyeblink response; CS, conditioned stimulus; GABA, γ-aminobutyric acid; LTD, long-term depression; MSC, muscimol; PC, Purkinje cell; pcd, Purkinje cell degeneration; pf, p
Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation
Keywords: محدود، افسردگی طولانی مدت; 5-HT, 5-hydroxytryptamine (serotonin); WDR, dorsal horn wide dynamic range; SNL, spinal nerve ligation; LTD, long-term depression; LTP, long-term potentiation; GABA, γ-amino-butyric acid; HPLC, high performance liquid chromatography; PWT, paw withdrawal t
Adolescent brain maturation, the endogenous cannabinoid system and the neurobiology of cannabis-induced schizophrenia
Keywords: محدود، افسردگی طولانی مدت; 2-AG, 2-arachidonoylglycerol; AMPA, alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate; Ca, calcium; CB, cannabinoid; COMT, catechol-O-methyl transferase; eCB, endocannabinoid; GABA, gamma-aminobutyric acid; LTD, long-term depression; LTP, long-term p
Sleep and hippocampus: Do we search for the right things?
Keywords: محدود، افسردگی طولانی مدت; LTD, long-term depression; LTP, long-term potentiation; NREM, non rapid eye movement; PGO, ponto-geniculo-occipital; REM, rapid eye movement; SWA, slow wave activity; SWS, slow wave sleepHippocampus; Memory consolidation; Non-REM; REM; Sleep
The GLUR2 subunit of AMPA receptors: Synaptic role
Keywords: محدود، افسردگی طولانی مدت; ABP, AMPA receptor binding protein; GluR2, ER, endoplasmic reticulum; LTD, long-term depression; LTP, long term potentiation; NARP, neuronal activity-regulated pentraxin; NSF, N-ethylmaleimide sensitive factor; PICK1, protein interacting with C-kinase-1;
LTP impairment by fractalkine/CX3CL1 in mouse hippocampus is mediated through the activity of adenosine receptor type 3 (A3R)
Keywords: محدود، افسردگی طولانی مدت; LTP, long-term potentiation; LTD, long-term depression; fEPSPs, field evoked post-synaptic potentials; CNS, central nervous system; mice CX3CR1GFP/GFP, mice lacking CX3CR1; A1R, adenosine A1 receptor; A2AR, adenosine A2A receptor; A2BR, adenosine A2B rece