Comparison of long-term potentiation (LTP) in the medial (monocular) and lateral (binocular) rat primary visual cortex

Recent evidence suggests that the primary visual cortex (V1) of rodents expresses surprisingly high levels of plasticity into adulthood. For example, long-term potentiation (LTP) is readily induced in the mature V1 of adult rodents in vivo. Here, adult, urethane-anesthetized rats were used for a detailed characterization of LTP in the pathway between the dorsal lateral geniculate nucleus (dLGN) and ipsilateral V1. Strong theta-burst stimulation (TBS) of the LGN resulted in LTP of field postsynaptic potentials (fPSPs) recorded in the lateral (binocular) aspects of V1 (l-V1), but failed to do so in the medial (monocular) V1 (m-V1). Administration of MK 801 (1 mg/kg, i.p.) blocked LTP in l-V1, indicative of a critical role of NMDA receptors in this effect. Interestingly, weaker TBS induction protocols resulted in synaptic depression in both l-V1 and m-V1, an effect that was blocked by MK 801 only in m-V1. Finally, dLGN stimulation also elicited long-latency fPSPs in the V1 contralateral to the stimulation site, likely reflecting polysynaptic activity crossing the midline via callosal fibers. Relative to ipsilateral recordings, contralateral fPSPs showed greater LTP in both V1 segments, which could not be blocked by MK 801 administration. Together, these data reveal clear differences in the expression of LTP at synapses in l-V1 and m-V1, with greater plasticity in the lateral V1 segment. Further, we confirm that NMDA receptors mediate some, but not all forms of synaptic plasticity in the V1 of adult rodents.

► Synaptic plasticity in the medial/monocular and lateral/binocular visual cortex of rats are compared.
► The medial/monocular cortex does not readily express long-term potentiation.
► The lateral/binocular visual cortex expresses long-term potentiation.
► Both segments express synaptic depression.
► There are clear differences in plasticity in the different segments of the rat visual cortex.