کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3064851 | 1580458 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
LTP impairment by fractalkine/CX3CL1 in mouse hippocampus is mediated through the activity of adenosine receptor type 3 (A3R)
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We have examined how the chemokine fractalkine/CX3CL1 influences long-term potentiation (LTP) in CA1 mouse hippocampal slices. Field potentials (fEPSPs) were recorded upon electrical stimulation of Schaffer collaterals. It was found that application of CX3CL1 inhibits LTP when present during the critical induction period. LTP impairment (i) failed to occur in CX3CR1 deficient mice (CX3CR1GFP/GFP) and in the presence of okadaic acid (OA); (ii) required the activation of adenosine receptor 3 (A3R), since it was prevented in A3R-deficient mice or by MRS1523, a selective A3R antagonist. Together, these findings indicate that CX3CL1 inhibits hippocampal LTP through A3R activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 215, Issues 1–2, 30 October 2009, Pages 36–42
Journal: Journal of Neuroimmunology - Volume 215, Issues 1–2, 30 October 2009, Pages 36–42
نویسندگان
Laura Maggi, Flavia Trettel, Maria Scianni, Cristina Bertollini, Fabrizio Eusebi, Bertil B. Fredholm, Cristina Limatola,