Impaired olfactory bulb neurogenesis depends on the presence of human wild-type alpha-synuclein

► Regulatable expression of human wild-type alpha-synuclein in the SVZ/OB neurogenic region. ► Impaired adult OB neurogenesis partially rescued in GCL/GLOM. ► Rescue of newly generated dopaminergic neurons in the OB. ► Intracytoplasmic BrdU+ particles within microglia indicate phagocytosis of new NPC.