Keywords: α-syn; alpha-synuclein; CNS; central nervous system; PD; Parkinson disease; CX3CR1; fractalkine receptor; CCR2; C-C chemokine receptor type 2; CCL2; C-C chemokine ligand 2; SNpc; substantia nigra pars compacta; GWAS; genome wide association studies; MHCI
مقالات ISI (ترجمه نشده)
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Keywords: α-syn; alpha-synuclein; AA; appendicitis/appendectomy; CCR; C-C chemokine receptor; CD; Crohn's disease; CXCR C-X-C; chemokine receptor; DSS; dextran sulfate sodium; GALT; gastrointestinal lymphoid tissue; IBD; inflammatory bowel disease; Ig; immunoglo
Keywords: α-Syn; α-synuclein; AD; Alzheimer's disease; BP; Biological Process; CAMS; Chinese Academy of Medical Sciences; CAPS; calcium-dependent activator of secretion; CC; Cellular component; CCK; Cell counting kit; DA; dopamine; DAVID; Database for annotation,
Keywords: 2D-DIGE; two-dimensional differential gel electrophoresis; 2DE; two-dimensional gel electrophoresis; ANOVA; analysis of variance; BSA; bovine serum albumin; BVA; biological variation analysis; CBB; Coomassie brilliant blue; CHAPS; 3-((3-cholamidopropyl) d
Keywords: α-Syn; α-synuclein; Aβ; beta-amyloid; AD; Alzheimer's disease; AON; anterior olfactory nucleus; ALS; amyotrophic lateral sclerosis; APP; amyloid precursor protein; CBD; corticobasal degeneration; CJD; Creutzfeldt-Jakob disease; DLB; dementia with Lewy
Keywords: Multiple system atrophy; PRNP; Prion disease; Prion protein; Sporadic Creutzfeld-Jakob disease; α-synuclein; α-syn; confidence intervals; CI; cytoplasmic inclusions; GCIs; multiple system atrophy; MSA; sporadic Creutzfeld-Jakob disease; sCJD; odds ratio
Keywords: α-Syn; alpha-synuclein; AD; Alzheimer's disease; ALS; Amyotrophic lateral sclerosis; AMD; Age related macular degeneration; APP; β-amyloid precursor protein; Aβ; Amyloid-beta; Cas; CRISPR associated protein; CRISPR; clustered regularly interspaced shor
Keywords: Aβ; β-amyloid; AD; Alzheimer's disease; APD; atipical parkinsonian diseases; α-syn; α-synuclein; CBS; corticobasal syndrome; DLB; dementia with lewy bodies; DLN; dorsolateral tegmental nucleus; MCI; mild cognitive impairment; HD; Huntington's dise
Keywords: α-synuclein; α-syn; APP; amyloid precursor protein; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; Aβ; β-amyloid; CSF; Cerebrospinal fluid; DLB; Dementia with Lewy Bodies; FTD; Fronto temporal dementia; IMR; immunomagnetic reduction; L
Keywords: AD; Alzheimer's disease; PD; Parkinson's disease; ssNMR; solid-state NMR; α-syn; α-synuclein; β2m; β2-microglobulin; apoA-I; apolipoprotein A-I; polyQ; polyglutamine; IDP; intrinsically disordered protein; htt; huntingtin; MD; molecular dynamics; MHC
Keywords: 3-HK; 3-hydroxykynurenine; 6-OHDA; 6-hydroxydopamine; A; Amygdala; ACMSD; 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; AD; Alzheimer's disease; AD; Anterodorsal nucleus (Thalamus); α-syn; Alpha-synuclein; CCL2; Chemokine (CC motif) ligand 2;
Keywords: Aβ; beta-amyloid peptide; AAV; adeno-associated virus; ABAD; amyloid-beta-binding alcohol dehydrogenase; AD; Alzheimer's disease; ALP; autophagy-lysosome pathways; Apaf-1; apoptic protease-activating factor 1; APP; amyloid precursor protein; AICD; APP in
Keywords: α-syn; α-synuclein; AD; Alzheimer's Disease; Al; aluminum; C. elegans; Caenorhabditis elegans; CPF; chlorpyrifos; DA; dopamine; DDE; dichlorodiphenyldichloroethylene; DDT; dichlorodiphenyltrichloroethane; ETC; electron transport chain; FAO; fatty acid
Keywords: α-GlcChol; 1-O-cholesteryl-α-d-glucopyranoside; α-Syn; α-synuclein; β-GlcChol; 1-Î-cholesteryl-β-d-glucopyranoside or β-cholesterylglucoside; BMP; bis (monoacylglycero) phosphate; CERT; ceramide transfer protein; CNS; central nervous system; ER; e
Keywords: 6-OHDA; 6-hydroxydopamine; α-syn; α-synuclein; ACC; Anterior Cingulate Cortex; ADMA; asymmetric dimethylarginine; Alda-1; N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide; Aldh1/Aldh2; aldehyde dehydrogenases 1/2; ALDH2; mitochondrial aldehyde dehyd
Keywords: α-syn; α-synuclein; Aβ; β-amyloid; AD; Alzheimer's disease; ADAMs; a disintegrin and metalloproteinases; ALS; amyotrophic lateral sclerosis; BSE; bovine spongiform encephalopathy; CJD; Creutzfeldt-Jakob disease; CNS; central nervous system; CSF; cer
Keywords: α-syn; alpha synuclein; Tf; transferrin; TfR; transferrin receptor; DA; dopamine; PD; Parkinson's disease; Tf-Fe; transferrin bound iron; NTBI; non transferrin bound iron; SN; substantia nigra; RPE; retinal pigment epithelium; OCT; optical coherence tomo
Keywords: OS; oxidative stress; CNS; central nervous system; ROS; reactive oxygen species; SOD; superoxide dismutase; CAT; catalase; Cu; copper; Zn; zinc; Mn; manganese; Fe; iron; Ni; nickel; DA; dopamine; PHOX; NADPH oxidase; Nrf2; nuclear factor erythroid 2-relat
Keywords: α-Syn; alpha-synuclein; CBE; conduritol-B-epoxide; CCCP; carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone; CS; citrate synthase; Cx I; mitochondrial respiratory chain complex I; DA; dopaminergic; DIV; day in vitro; DMSO; dimethyl sulfoxide; EDTA; eth
Keywords: α-syn; α-synuclein; Aβ; β-amyloid peptide; AD; Alzheimer's disease; ALCAM; activated leukocyte cell adhesion molecule; ALS; amyotrophic lateral sclerosis; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; APCs; antigen-presenting cells; BBB
Keywords: MSA; multiple system atrophy; MSA-P; parkinsonian variant of MSA; MSA-C; cerebellar variant of MSA; α-Syn; alpha-synuclein; SND; striatonigral degeneration; OPCA; olivopontocerebellar atrophy; GCI; (oligodendro-)glial cytoplasmic inclusions; UMSARS; unif
Keywords: α-syn; α-synuclein; ASK1; Apoptosis signaling-regulating kinase 1; CMA; Chaperone-mediated autophagy; DAT; Dopamine transporter; ETC; Electron transport chain; iPS; Induced pluripotent stem; LAMP-2A; Lysosome-associated membrane protein 2A; LB; Lewy bod
FKBP12-immunopositive inclusions in patients with α-synucleinopathies
Keywords: AD; Alzheimer's disease; α-SYN; α-Synuclein; AT8; anti-human PHF-tau monoclonal; DAB; 3,3â²-diaminobenzidine tetrahydrochloride; DLB; dementia with Lewies; FKBP12; FK506 binding protein 12; GCI; glial cytoplasmic inclusion; MSA; multiple system atrop
Stimulation of α-synuclein amyloid formation by phosphatidylglycerol micellar tubules
Keywords: α-Syn; α-Synuclein; PD; Parkinson's disease; L/P; lipid-to-protein; POPG; 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1â²-rac-glycerol); POPA; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphate; POPS; 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-l-serine; POPG-d3
MicroRNA-7 facilitates the degradation of alpha-synuclein and its aggregates by promoting autophagy
Keywords: α-Syn; alpha-Synuclein; bFGF; basic fibroblast growth factor; DMEM; Dulbecco's modified Eagle's medium; EGF; epidermal growth factor; miR-7; microRNA-7; miR-SC; scrambled microRNA control; MPTP; 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine; PD; Park
Plasma α-synuclein and cognitive impairment in the Parkinson's Associated Risk Syndrome: A pilot study
Keywords: PD; Parkinson's disease; DAT; dopamine transporter; PARS; Parkinson's Associated Risk Syndrome; AD; Alzheimer's disease; α-syn; alpha-synuclein; CSF; cerebrospinal fluid; UPSIT; University of Pennsylvania Smell Identification Test; [123]β-CIT; [123I]-fl
P75 Involved in the Ubiquitination of α-synuclein in Rotenone-based Parkinson's Disease Models
Keywords: P75; siAH; p65; α-syn; Parkinson's disease (PD); ubiquitination;
Manganese exposure: Linking down-regulation of miRNA-7 and miRNA-433 with α-synuclein overexpression and risk of idiopathic Parkinson's disease
Keywords: BCL2; B-cell CLL/lymphoma 2; CCND1; cyclin D1; CCNE1; cyclin E1; CRKL; V-Crk avian sarcoma virus CT10 oncogene homolog-like; FGF20; fibroblast growth factor 20; FGF7; fibroblast growth factor 7; FOXO1; forkhead box protein O1A; GRB2; growth factor recepto
Correlations between CSF proteins and spontaneous neuronal activity in Parkinson's disease
Keywords: BJLO; Benton Judgment of Line Orientation; fALFF; fractional amplitude of low-frequency fluctuation; HVLT-R; Hopkins Verbal Learning Test-Revised; HVLT-R_Dis_Rec; Hopkins Verbal Learning Test-Revised recognition discrimination index; LNS; Letter Number Se
The small heat shock proteins, especially HspB4 and HspB5 are promising protectants in neurodegenerative diseases
Keywords: α-Crystallins; Neurodegenerative diseases; Neuroprotection; Gene regulation; Aβ; β-amyloid peptides; AD; Alzheimer's disease; ALS; Amyotrophic lateral sclerosis; AxD; Alexander's disease; CNS; Central nervous system; EAE; experimental autoimmune enceph
Phospholipase D1 downregulation by α-synuclein: Implications for neurodegeneration in Parkinson's disease
Keywords: α-syn; alpha synuclein; AU; arbitrary units; CF; cytosolic fraction; DAG; diacylglycerol; ERK; extracellular signal-regulated kinase; ev; IMR-32 cell line stably transfected with pcDNA empty vector; IMR32; human neuroblastoma cell line; LW; Lewy bodies;
Lipid metabolism alterations in the neuronal response to A53T α-synuclein and Fe-induced injury
Keywords: Dopaminergic neurons; A53T α-synuclein; Iron; Oxidative stress; Triacylglycerol; Lipid metabolism; ACS; Acyl-CoA synthetase; α-syn; α-synuclein; A53T α-syn cell; N27 neurons expressing the vector pcDNA3-A53T α-synuclein; BSA; bovine serum albumin; Ch
Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease
Keywords: α-Syn; alpha-Synuclein; h-α-Syn; transgenic human alpha-Synuclein; D1 receptor; dopamine receptor type 1; D2 receptor; dopamine receptor type 2; DA; dopamine; DAT; dopamine transporter; VMAT2; vesicular monoamine transporter 2; DOPAC; 3,4-dihydroxypheny
C-terminal truncation exacerbates the aggregation and cytotoxicity of α-Synuclein: A vicious cycle in Parkinson's disease
Keywords: α-Syn; alpha-synuclein; α-Syn FL; full-length alpha-synuclein; α-Syn121; C-terminal truncated alpha-synuclein 1-121; C19; C-terminal 19-residues peptide of alpha-synuclein; CD; circular dichroism; DLB; dementia with Lewy bodies; DLS; dynamic light scat
The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson's disease brain in association with the pathologic accumulation of alpha-synuclein
Keywords: 4-MUG; 4-methylumbelliferone α-d-galactopyranoside; GalNAc; N-acetyl-d-galactosamine; α-Gal A; alpha-Galactosidase A; α-syn; alpha-synuclein; ALP; autophagy-lysosome pathway; Cat B; cathepsin B; Cat D; cathepsin D; Gb3; globotriaosylceramide; lyso-Gb3;
Epothilone D inhibits microglia-mediated spread of alpha-synuclein aggregates
Keywords: α-syn; α-Synuclein; EpoD; Epothilone D; MSA; Multiple System Atrophy; PD; Parkinson's Disease; CNS; Central nervous system; DLB; Dementia with Lewy Bodies; LB; Lewy Bodies; GCI; Glial Cytoplasmic Inclusion; PMA; Phorbol-12-Myristate-13-Acetate; HAPI; Hi
Autophagy in hemorrhagic stroke: Mechanisms and clinical implications
Keywords: AIM2; absent in melanoma 2; AMPK; Adenosine 5â² monophosphate-activated protein kinase; ASC; apoptosis-associated speck-like protein containing a CARD; BBB; blood-brain barrier; BH3; Bcl-2 homology 3; BMVECs; brain microvascular endothelial cells; BNIP3;
Mitochondrial ROS-mediated post-transcriptional regulation of α-synuclein through miR-7 and miR-153
Keywords: α-SYN; alpha-synuclein; ROS; reactive oxygen species; 3â²-UTR; 3â²-untranslated region; DAT; dopamine transporter; MPP+; 1-methyl-4-phenylpyridinium; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; α-synuclein; microRNA; 3â²-UTR; Mitochondria; Pa
Research articleNeuroprotective effects of lentivirus-mediated cystathionine-beta-synthase overexpression against 6-OHDA-induced parkinson's disease rats
Keywords: PD; parkinson's disease; DA; dopaminergic; SN; substantia nigra; H2S; hydrogen sulfide; CBS; cystathionine-beta-synthas; 6-OHDA; 6-Hydroxydopamine; SOD; superoxide dismutase; GSH-Px; glutathione peroxidase; MDA; mlonic dialdehyde; α-SYN; α-synuclein; AO
Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
Keywords: α-SYN; alpha synuclein; β-TrCP; β-transducin repeat containing E3 ubiquitin protein ligase; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AMPK; AMP-activated protein kinase; ARE; antioxidant response element; ASK1; apo
Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy
Keywords: AEBSF; 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride; α-syn; α-synuclein; BiFC; bimolecular fluorescence complementation; CT; C-terminal; DLB; dementia with Lewy bodies; ER; endoplasmic reticulum; mAbs; monoclonal antibodies; MSA; multiple syst
Research PaperFunctional alterations of the dopaminergic and glutamatergic systems in spontaneous α-synuclein overexpressing rats
Keywords: α-syn; α-synuclein; m/m; homozygous mutant rats;  +/+;  control animals; PD; Parkinson's disease; LBs; Lewy bodies; SNpc; substantia nigra pars compacta; VTA; ventral tegmental area; DA; dopamine; DAergic neurons; dopaminergic neurons; MSNs; medium sp
Review articleDeregulation of α-synuclein in Parkinson's disease: Insight from epigenetic structure and transcriptional regulation of SNCA
Keywords: α-synuclein; Parkinson's disease; Epigenetics; Gene regulation; DNA methylation; Histone post translational modification; α-SYN; α-synuclein; CGI; CpG island; CTD; c-terminal domain; DA; dopaminergic neurons; DLB; Diffuse Lewy Body; ENCODE; Encyclopedi
Altered dendritic cell subset distribution in patients with Parkinson's disease: Impact of CMV serostatus
Keywords: α-syn; alpha-synuclein; CMV; cytomegalovirus; ILT; Ig-like transcript; mDC; myeloid dendritic cells; pDC; plasmacytoid dendritic cells; UPDRS; unified Parkinson disease rating scale; TLR; toll-like receptor; Plasmacytoid dendritic cells; Myeloid dendriti
Baicalein inhibits α-synuclein oligomer formation and prevents progression of α-synuclein accumulation in a rotenone mouse model of Parkinson's disease
Keywords: PD; Parkinson disease; α-syn; α-synuclein; SN; substantia nigra; LBs; Lewy bodies; PFA; paraformaldehyde; TH; tyrosine hydroxylase; PBS; phosphate buffered saline; ChAT; choline acetyltransferase; HPLC; high performance liquid chromatography; DA; dopami
Sporadic Creutzfeldt-Jakob disease diagnostic accuracy is improved by a new CSF ELISA 14-3-3γ assay
Keywords: α-syn; alpha-synuclein; AD; Alzheimer's disease; ApoE; apolipoprotein E gene; CNS; central nervous system; CSF; cerebrospinal fluid; CV; coefficient of variation; EEG; electroencephalogram; ELISA; enzyme-linked immunosorbent assay; ERK; extracellular s
Research PaperAberrant adenosine A2A receptor signaling contributes to neurodegeneration and cognitive impairments in a mouse model of synucleinopathy
Keywords: α-Syn; α-synuclein; A2AR; adenosine A2A receptor; AD; Alzheimer's disease; DG; dentate gyrus; DLB; dementia with Lewy bodies; HD; Huntington's disease; KO; knockout; LBs; Lewy bodies; LNs; Lewy neurites; MSA; multiple system atrophy; PD; Parkinson's dis
Early-onset motor impairment and increased accumulation of phosphorylated α-synuclein in the motor cortex of normal aging mice are ameliorated by coenzyme Q
Keywords: PD; Parkinson's disease; CoQ; coenzyme Q; Q; oxidized coenzyme Q; QH2; reduced coenzyme Q; OCR; oxygen consumption rate; α-syn; alpha-synuclein; VGluT1; vesicular glutamate transporter 1; SNc; substantia nigra pars compacta; LBs; Lewy bodies; TH; tyrosin
Basic neuroscienceHigh-content analysis of α-synuclein aggregation and cell death in a cellular model of Parkinson's disease
Keywords: Alpha-synuclein; High-content analysis; Aggregation; Cell death; Parkinson's disease; α-SYN; alpha-synuclein; PD; Parkinson's disease; HCA; high-content analysis; Thio S; Thioflavin S; LDH; lactate dehydrogenase;
Histone H3 acetylation in the postmortem Parkinson's disease primary motor cortex
Keywords: MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 6-OHDA; 6-hydroxydopamine; AcH3; acetylated histone H3; AcH3K9; acetylated histone H3 lysine 9; AcH3K14; acetylated histone H3 lysine 14; AcH3K18; acetylated histone H3 lysine 18; AcH3K23; acetylated his