کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8841589 | 1615026 | 2018 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Correlations between CSF proteins and spontaneous neuronal activity in Parkinson's disease
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
α-Synt-tauAβ42SDMTHVLT-RLNsSymbol Digit Modalities TestP-Tau - P سالAlpha-synuclein - آلفا سینوئولینParkinson’s disease - بیماری پارکینسونphosphorylated tau - تئو فسفورلیت شدهfunctional magnetic resonance imaging - تصویرسازی تشدید مغناطیسی کارکردیTotal tau - تعداد کلfractional amplitude of low-frequency fluctuation - دامنه کسری نوسانات فرکانس پایینSemantic fluency - روانشناسی معناییfALFF - فالفSpontaneous neuronal activity - فعالیت عصبی خود به خودی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The relationship between cerebrospinal fluid (CSF) proteins and brain function in Parkinson's disease (PD) is not explained clearly. We investigated the correlations between CSF proteins and spontaneous neuronal activity in PD patients via fractional amplitude of low-frequency fluctuation (fALFF) using the Parkinson's Progression Markers Initiative database. Twenty-eight PD patients underwent resting-state functional magnetic resonance imaging in “off” status and lumbar puncture within a month. Correlation analyses between CSF proteins and fALFF value in whole brain as well as clinical assessment scores were performed. We found CSF total tau (t-tau) level was negatively correlated with fALFF in posterior cingulate gyrus. And fALFF in posterior cingulate gyrus was positively correlated with Hopkins Verbal Learning Test-Revised recognition discrimination index. Besides, alpha-synuclein (α-syn) level was correlated with fALFF in bilateral inferior frontal gyrus. This study provides evidence that CSF proteins may have a relationship with brain function related to cognitive status in PD patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 673, 23 April 2018, Pages 61-66
Journal: Neuroscience Letters - Volume 673, 23 April 2018, Pages 61-66
نویسندگان
Tao Guo, Xiaojun Guan, Qiaoling Zeng, Min Xuan, Quanquan Gu, Xiaojun Xu, Minming Zhang,