کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4338491 1614870 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sex-specific changes in gene expression and behavior induced by chronic Toxoplasma infection in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Sex-specific changes in gene expression and behavior induced by chronic Toxoplasma infection in mice
چکیده انگلیسی

There is growing evidence that Toxoplasma gondii modifies the behavior of its intermediate hosts. We investigated the molecular basis of these infection-induced behavioral changes, followed by five related behavioral tests to assess the extent of biological relevance. Gene expression signatures were generated in the frontal cortex of male and female mice during the latent stage of infection. We found marked sex-dependent expression differences in mice. In female mice, Toxoplasma infection altered the expression of genes involved in the development of the forebrain, neurogenesis, and sensory and motor coordination (i.e. downregulation of fatty acid-binding protein 7 and eyes absent homolog 1, upregulation of semaphorin 7A). In male mice, infection led mainly to modulation of genes associated with olfactory function (i.e. downregulation of a number of olfactory receptors and dopamine receptor D4, upregulation of slit homolog 1). Although infection appears to affect the olfactory function in male mice, it is the female but not male mice that exhibited attraction to cat odor. In contrast, infected male mice showed a deficit in social transmission of food preference. In contrast to males, infected females displayed locomotor hyperactivity in open field. General olfaction and sensorimotor gating were normal in both male and female infection. Our results indicate that the sex of the host plays a major role in determining variable brain and behavior changes following Toxoplasma infection. These observations are consistent with heterogeneity of neuropsychiatric outcomes of the infection in humans.

▶We investigated molecular changes caused by persistent Toxoplasma infection in mice. ▶We found marked sex-dependent effects on gene transcription of the frontal cortex. ▶The sex-dependent effects were supported by sex-specific behavioral abnormalities. ▶The sex of the host plays an important role in the response to Toxoplasma infection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 206, 29 March 2012, Pages 39–48
نویسندگان
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