Persistent effects of early augmented acoustic environment on the auditory brainstem

Acoustic experiences significantly shape the functional organization of the auditory cortex during postnatal “critical periods.” Here, we investigate the effects of a non-traumatic augmented acoustic environment (AAE) on the central nucleus of the inferior colliculus (ICC) and lower brainstem nuclei in rat during the critical period. Our results show that an AAE during P9–P28 had a persistent effect on the evoked auditory brainstem responses leading to a decreased latency and an increased amplitude of the response at and above the frequency of the stimulus used for the AAE. These findings are correlated with increased numbers of sites in the ICC that responded to the AAE frequency and show higher thresholds. There also were persistent effects in neurons with a best frequency higher than the AAE stimulus. These neurons showed decreased activity at low sound levels in the low frequency tail of the frequency response area. This was at, below and above the AAE stimulus frequency. Less often, increased activity at higher sound levels also was seen. Together, these findings suggest multifaceted interactions between activity-dependent plasticity, homeostasis, and development in the brainstem during the initial stages of hearing. A neonate exposed to an altered auditory environment may experience long-lasting change over the entire network of the auditory system.

▶An augmented acoustic environment during development induces permanent change in the brainstem. ▶Acoustic environment contributes to a proper maturation of the auditory brainstem. ▶Tonotopic maps in midbrain over-represent stimuli from the neonatal environment. ▶ABR signals increase in auditory brainstem after a neonatal stimulus.