کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4339485 | 1295756 | 2010 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Elevated response of human amygdala to neutral stimuli in mild post traumatic stress disorder: neural correlates of generalized emotional response
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کلمات کلیدی
Clinician Administered PTSD ScaleCAPSSPMAmygdala - آمیگدال، بادامهpost-traumatic stress disorder - اختلال استرس پس از ضربهPost-traumatic stress disorder (PTSD) - اختلال استرس پس از ضربه (PTSD)PTSD - اختلال استرسی پس از ضایعه روانیFunctional magnetic resonance imaging (fMRI) - افامآرآی، تصویرسازی تشدید مغناطیسی کارکردی analysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancefMRI - تصویرسازی تشدید مغناطیسی کارکردیfunctional magnetic resonance imaging - تصویرسازی تشدید مغناطیسی کارکردیreaction time - زمان واکنشStatistical parametric map - نقشه پارامتری آماریEmotion - هیجانPosterior commissure - کمربند عقبanterior commissure - کمربند قدامی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Previous evidence from functional magnetic resonance imaging (fMRI) studies has shown that amygdala responses to emotionally neutral pictures are exaggerated at a group level in patients with severe post-traumatic stress disorder (PTSD) [Hendler T, Rotshtein P, Yeshurun Y, Weizmann T, Kahn I, Ben-Bashat D, Malach R, Bleich A (2003) Neuroimage 19(3):587-600]. The present fMRI study tested the hypothesis that amygdala responses are elevated not only in response to negative pictures but also to neutral pictures as a function of disease severity in patients with mild symptoms and in subjects who did not develop symptoms. To this end, fMRI scans were performed in 10 patients with mild PTSD and 10 healthy controls (both victims of a bank robbery), during the execution of a visuo-attentional task in which they were asked to observe emotionally negative or neutral pictures. Control subjects showed enhanced amygdala responses to emotionally negative stimuli compared to neutral stimuli. On the contrary, PTSD patients were characterized by high amygdala responses to both neutral and emotional pictures, with no statistically significant difference between the two classes of stimuli. In the entire group, we found correlations among the severity of the PTSD symptoms, task performance, and amygdala activation during the processing of neutral stimuli. Results of this study suggest that amygdala responses and the selectivity of the emotional response to neutral stimuli are elevated as a function of disease severity in PTSD patients with mild symptoms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 168, Issue 3, 14 July 2010, Pages 670-679
Journal: Neuroscience - Volume 168, Issue 3, 14 July 2010, Pages 670-679
نویسندگان
M. Brunetti, G. Sepede, G. Mingoia, C. Catani, A. Ferretti, A. Merla, C. Del Gratta, G.L. Romani, C. Babiloni,